MSN8C
MSN8C, an analog of mansonone E, is a novel catalytic inhibitor of human DNA topoisomerase II. MSN8C induces cancer cell apoptosis. MSN8C shows significant anti-tumor cell proliferation activity in vitro.
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- No. CAS: 1314798-31-6
- Fòrmula: C13H10O3
- Peso molecular:214.22
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Almacenamiento:
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CNE-2 | IC50 |
2.05 μM
Compound: 7
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Antitumor against human CNE2 cells assessed as cell survival after 48 hrs by MTT assay
Antitumor against human CNE2 cells assessed as cell survival after 48 hrs by MTT assay
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[PMID: 21600681] |
MSN8C prevents supercoiled DNA from entering the catalytic cycle to avoid capture by Topo II poisons and reduces fragmented DNA generation[1].
MSN8C (1-10 μM, 24 h) induces HL-60 cancer cell apoptosis via increases caspases-3 expression in a dose-dependent manner.[1].
MSN8C (1, 5, 10, 20 μM, 12 h) increases caspase-8 and caspase-9 activity in HL-60 cells[1].
MSN8C (48 h) inhibits human 11 tumor cell lines from various origins with an average IC50 value of 2.6 µM[1].
MSN8C has strong antiproliferative effects on the human breast cancer adriamycin (HY-15142)-resistant cell line MCF-7/Adr and mitoxantrone (HY-13502)-resistant cell line HL-60/MX2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HL-60 cells
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Concentration:10 μM
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Incubation Time:1 h
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Result:Reduced γ-H2AX expression levels.Weakened the production of γ-H2AX by VP-16.
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Cell Line:HL-60 cells
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Concentration:1, 5, 10, 20 μM
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Incubation Time:1, 5, 10, 20 μM
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Result:Induced caspases-3 express in a dose-dependent manner.
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Cell Line:HL-60 cells
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Concentration:5, 10 μM
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Incubation Time:12 h
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Result:Promoted caspase-8 and caspase-9 activity in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:A549 tumor xenograft model, female BALB/c nude mice[1]
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Dosage:10 mg/kg
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Administration:Intraperitoneal injection (i.p.), two-day intervals for 2 weeks
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Result:Inhibits tumor with the tumor weight inhibition (TWI) value of 74.2%.
Chemical Information
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No. CAS 1314798-31-6
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Peso molecular 214.22
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Fòrmula C13H10O3
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SMILES
CC(CO1)C2=C(C1=CC(C3=O)=O)C3=CC=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MSN8C Related Classifications
HY-149410 Related Classifications
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