NBD-125
NBD-125 (B-12), a berberine analogue, is an RXRα activator, with an IC50 of 31.10 μM in KM12C cell.
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- No. CAS: 2367641-24-3
- Fòrmula: C19H18ClNO2
- Peso molecular:327.80
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
27.17 μM
Compound: B-12
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Inhibition of cell proliferation of human HCT116 cells incubated for 15 hrs by MTT assay
Inhibition of cell proliferation of human HCT116 cells incubated for 15 hrs by MTT assay
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[PMID: 32391701] |
| KM12C | IC50 |
31.1 μM
Compound: B-12
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Inhibition of cell proliferation of human KM12C cells incubated for 15 hrs by MTT assay
Inhibition of cell proliferation of human KM12C cells incubated for 15 hrs by MTT assay
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[PMID: 32391701] |
| SW-620 | IC50 |
36.19 μM
Compound: B-12
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Inhibition of cell proliferation of human SW620 cells incubated for 15 hrs by MTT assay
Inhibition of cell proliferation of human SW620 cells incubated for 15 hrs by MTT assay
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[PMID: 32391701] |
In Vitro
NBD-125 (B-12) exhibits the strongest transcriptional activation ability to RXRα and the greatest inhibitory effect on colon cancer cell growth[1].
NBD-125 (B-12, 0-80, μM) inhibits β-catenin signaling and cell proliferation in colon cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Km12c, HCT116 and SW620 cell lines.
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Concentration:0-50 μM, 0-60, 0-80 μM.
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Incubation Time:15 h.
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Result:Downregulated c-Myc, Cdc42 protein levels.
Chemical Information
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No. CAS 2367641-24-3
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Peso molecular 327.80
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Fòrmula C19H18ClNO2
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SMILES
COC1=C2C=[N+](CCC3=C4C=CC(OC)=C3)C4=CC2=CC=C1.[Cl-]
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NBD-125 Related Classifications
HY-133739 Related Classifications
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