Neomycin C
Neomycin C is an impurity of Neomycin (HY-150520) and a stereoisomer of Neomycin B (HY-17624). Neomycin C exerts in vitro antimicrobial activity against Staphylococcus epidermidis and Staphylococcus aureus. Neomycin C can be used for the research of bacterial infection.
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- No. CAS: 66-86-4
- Fòrmula: C23H46N6O13
- Peso molecular:614.64
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
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Aminoglycoside |
In Vitro
Chemical Information
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No. CAS 66-86-4
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Peso molecular 614.64
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Fòrmula C23H46N6O13
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SMILES
N[C@@H]1[C@@H](O[C@@H]2[C@H](N)[C@@H](O)[C@H](O)[C@@H](CN)O2)[C@H](O[C@H]3[C@H](O)[C@H](O[C@@H]4[C@H](N)[C@@H](O)[C@H](O)[C@@H](CN)O4)[C@@H](CO)O3)[C@@H](O)[C@H](N)C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Pureza y Documentación
Referencias
[1]. Robertson JH, et al. Antimicrobial activity of neomycin C against Staphylococcus epidermidis. Appl Microbiol. 1971;22(6):1164-1165. [Content Brief]
[2]. Zheng J, et al. Component Optimization of Neomycin Biosynthesis via the Reconstitution of a Combinatorial Mini-Gene-Cluster in Streptomyces fradiae. ACS Synth Biol. 2020 Sep 18;9(9):2493-2501. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Neomycin C Related Classifications
HY-131130 Related Classifications
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