Nicothiazone
Nicothiazone is an α-glucosidase inhibitor with a yeast α-glucosidase IC50 of 120.20 μM. Nicothiazone inhibits α-glucosidase enzyme activity. Nicothiazone can be used for the research of type-II diabetes mellitus.
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- No. CAS: 555-90-8
- Fòrmula: C7H8N4S
- Peso molecular:180.23
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
α‑glucosidase 120.20 μM (IC50) |
In Vitro
Nicothiazone (compound 1) (10 min pre-incubation; 30 min reaction incubation) potently inhibits Baker's yeast α-glucosidase with an IC50 of 120.20 μM, showing greater potency than Acarbose (HY-B0089)[1].
Nicothiazone interacts with Saccharomyces cerevisiae α-glucosidase via hydrogen bonding with residues Asp349 and His111, supporting its inhibitory activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 555-90-8
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Peso molecular 180.23
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Fòrmula C7H8N4S
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SMILES
S=C(N)NN=CC=1C=NC=CC1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nicothiazone Related Classifications
HY-119534 Related Classifications
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