Nimucitinib
Based on 1 Customer Validation
Nimucitinib is a selective JAK inhibitor with potent tear secretion-promoting activity. Nimucitinib downregulates relevant signal transduction pathways by inhibiting the catalytic activity of JAK family tyrosine kinases. Nimucitinib promotes tear secretion in rabbits and inhibits corneal injury in rats. Nimucitinib can be used in dry eye-related research.
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- Pureza : 99.27%
- No. CAS: 2740557-24-6
- Fòrmula: C25H26F2N6O2
- Peso molecular:480.51
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
In Vivo
Nimucitinib (0.003-0.01% solution; eye drop; 6 times per day for 11 consecutive days; 5 μL each time) inhibits corneal injury in a rat model of dry eye induced by extraorbital lacrimal gland excision[1].
Nimucitinib (0.01% solution, administered via ocular instillation, 50 μL per dose, four times daily for 10 consecutive days) promotes tear secretion in a rabbit model of atropine-induced dry eye[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:JW white rabbit (male, weight ~2 kg)[1]
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Dosage:0.001% solution; 0.01% solution
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Administration:ocular instillation; single dose; 50 μL
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Result:Increased tear volume by 131% compared to pre-administration in the 0.001% solution group.
Increased tear volume by 168% compared to pre-administration in the 0.01% solution group.
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Animal Model:JW white rabbit (male, weight ~2 kg, atropine-induced dry eye model)[1]
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Dosage:0.01% solution
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Administration:ocular instillation; 4 times daily; 10 days; 50 μL
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Result:Increased tear volume by 151% compared to pre-administration.
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Animal Model:SD rat (male, 6 weeks old, extraorbital lacrimal gland excision-induced dry eye model)[1]
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Dosage:0.003% solution; 0.01% solution
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Administration:ocular instillation; 6 times daily; 11 days; 5 μL
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Result:Resulted in a corneal damage score of 13.0 in the 0.003% solution group.
Resulted in a corneal damage score of 10.5 in the 0.01% solution group.
Chemical Information
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No. CAS 2740557-24-6
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Appearance Solid
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Peso molecular 480.51
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Fòrmula C25H26F2N6O2
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Color Off-white to light yellow
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SMILES
FC1=CC(F)=CC(CNC2=CC(NC3=CC(NC([C@H]4CCCNC4)=O)=CC=C3)=NC=C2C(N)=O)=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 125 mg/mL (260.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureza y Documentación
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Ficha de datos (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0811 mL | 10.4056 mL | 20.8112 mL | 52.0281 mL |
| 5 mM | 0.4162 mL | 2.0811 mL | 4.1622 mL | 10.4056 mL | |
| 10 mM | 0.2081 mL | 1.0406 mL | 2.0811 mL | 5.2028 mL | |
| 15 mM | 0.1387 mL | 0.6937 mL | 1.3874 mL | 3.4685 mL | |
| 20 mM | 0.1041 mL | 0.5203 mL | 1.0406 mL | 2.6014 mL | |
| 25 mM | 0.0832 mL | 0.4162 mL | 0.8324 mL | 2.0811 mL | |
| 30 mM | 0.0694 mL | 0.3469 mL | 0.6937 mL | 1.7343 mL | |
| 40 mM | 0.0520 mL | 0.2601 mL | 0.5203 mL | 1.3007 mL | |
| 50 mM | 0.0416 mL | 0.2081 mL | 0.4162 mL | 1.0406 mL | |
| 60 mM | 0.0347 mL | 0.1734 mL | 0.3469 mL | 0.8671 mL | |
| 80 mM | 0.0260 mL | 0.1301 mL | 0.2601 mL | 0.6504 mL | |
| 100 mM | 0.0208 mL | 0.1041 mL | 0.2081 mL | 0.5203 mL |
Nimucitinib Related Classifications
HY-148785 Related Classifications
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