NMK-TD-100
NMK-TD-100 is a modulator for microtubule. NMK-TD-100 binds to tubulin, inhibits the tubulin polymerization with an IC50 of 17.5 µM, inhibits mitosis, and decreases mitochondrial membrane potential (MMP). NMK-TD-100 inhibits the proliferation of HeLa with an IC50 of 1.42 µM, arrests cell cycle at G2/M phase, induces apoptosis in HeLa.
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- No. CAS: 1252802-38-2
- Fòrmula: C19H17N3O3S
- Peso molecular:367.42
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
Actividad biológica
Descripciòn
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | IC50 |
168.5 μM
Compound: 5f
|
Cytotoxicity against human DU145 cells after 48 hrs by MTT assay
Cytotoxicity against human DU145 cells after 48 hrs by MTT assay
|
[PMID: 20692741] |
| LNCaP | IC50 |
40 μM
Compound: 5f
|
Cytotoxicity against human LNCAP cells after 48 hrs by MTT assay
Cytotoxicity against human LNCAP cells after 48 hrs by MTT assay
|
[PMID: 20692741] |
| MCF7 | IC50 |
144.9 μM
Compound: 5f
|
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
|
[PMID: 20692741] |
| MDA-MB-231 | IC50 |
54.5 μM
Compound: 5f
|
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
|
[PMID: 20692741] |
| MIA PaCa-2 | IC50 |
14.2 μM
Compound: 5f
|
Cytotoxicity against human MIAPaCa2 cells after 48 hrs by MTT assay
Cytotoxicity against human MIAPaCa2 cells after 48 hrs by MTT assay
|
[PMID: 20692741] |
| PC-3 | IC50 |
29.3 μM
Compound: 5f
|
Cytotoxicity against human PC3 cells after 48 hrs by MTT assay
Cytotoxicity against human PC3 cells after 48 hrs by MTT assay
|
[PMID: 20692741] |
Chemical Information
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No. CAS 1252802-38-2
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Peso molecular 367.42
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Fòrmula C19H17N3O3S
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SMILES
COC1=C(C(OC)=CC(C2=NN=C(S2)C3=CNC4=C3C=CC=C4)=C1)OC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)