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Referencia número: HY-182643

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NO-794

NO-794 is a histamine H₂ receptor antagonist. NO-794 inhibits gastric acid secretion in pylorus-ligated rats. NO-794 can be used for the research of peptic ulcers.

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No. CAS: 105150-87-6
Fòrmula: C₂₃H₂₈N₄O₂
Peso molecular:392.49

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

NO-794 Chemical Structure

No. CAS: 105150-87-6

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Actividad biológica

Descripciòn

NO-794 is a histamine H₂ receptor antagonist. NO-794 inhibits gastric acid secretion in pylorus-ligated rats. NO-794 can be used for the research of peptic ulcers^[1].

IC₅₀ & Target^[1]

H₂ Receptor

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In Vitro

NO-794 (0-30 min) is a potent, time-dependent and irreversible histamine H₂ receptor antagonist acting on dispersed guinea pig gastric mucosal cells, with a -log K_B value of 8.4^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NO-794 (0.5-2 mg/kg; intradermal injection; single administration) potently inhibits gastric acid secretion in pylorus-ligated rats, with an ED₅₀ of 0.9 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar (male, 180-210 g, pylorus-ligated model)^[1]
Dosage:

0.5 mg/kg; 1.0 mg/kg; 2 mg/kg
Administration:

i.d.; single dose
Result:

Reduced gastric acid output compared to controls at 0.5 mg/kg.
Significantly reduced gastric acid output by greater margins at 1.0 mg/kg and 2.0 mg/kg.
Achieved an ED50 value of 0.9 mg/kg for reduction of gastric acid secretion.
Demonstrated approximately 14 times more potency than ranitidine.

Chemical Information

No. CAS 105150-87-6
Peso molecular 392.49
Fòrmula C₂₃H₂₈N₄O₂
SMILES

O=C1NC(NCCCOC2=CC=CC(CN3CCCCC3)=C2)=NC4=C1C=CC=C4
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Oshita M, et al. Pharmacological studies of 2-(3-(3-(1-piperidinylmethyl)-phenoxy)propylamino)-4 (3H)-quinazolinone (NO-794), a new histamine H2-receptor antagonist. Jpn J Pharmacol. 1986 Oct;42(2):229-35. [Content Brief]

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NO-794

Ver todos los productos específicos de isoformas Histamine Receptor

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HY-182643 Related Classifications