NS3694
Based on 1 Customer Validation
NS3694, a diarylurea compound, is an apoptosome inhibitor. NS3694 inhibits apoptosome formation and caspase activation.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.88%
- No. CAS: 426834-38-0
- Fòrmula: C15H10ClF3N2O3
- Peso molecular:358.70
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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High-Throughput Bioactive Compound Library
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
5 μM
Compound: 2b
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Antagonist activity at human homomeric GluR5 expressed in HEK293 cells assessed as inhibition of intracellular calcium concentration by FLIPR assay
Antagonist activity at human homomeric GluR5 expressed in HEK293 cells assessed as inhibition of intracellular calcium concentration by FLIPR assay
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[PMID: 15615543] |
| HEK293 | IC50 |
5 μM
Compound: 2g/6e
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In vitro inhibitory activity against human ionotropic glutamate receptor ionotropic kainate 1 (GluR-5) expressed in HEK293 cells.
In vitro inhibitory activity against human ionotropic glutamate receptor ionotropic kainate 1 (GluR-5) expressed in HEK293 cells.
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[PMID: 14667236] |
When cell extracts are stimulated with cytochrome c and dATP in the presence of NS3694 (10-100 μM; 120 min), a dose-dependent inhibition of caspase 9, 3, and 7 processing, DFF45/ICAD and PARP cleavage, and DEVDase activity is observed[1].
NS3694 (10-100 μM) inhibits TNF-induced effector caspase activation and apoptosis in MCF-casp3 cells[1].
NS3694 specifically suppresses the cytochrome C-induced formation of apoptosome complex and caspase-9 activation, thus inhibiting the mitochondria-mediated apoptosis. NS3694 inhibits the formation of the apoptosome Apaf-1 by blocking the activation of the initiator caspase-9[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cells
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Concentration:10 μM, 50 μM, 100 μM
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Incubation Time:120 min
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Result:Inhibited cytochrome c- and dATP-induced DEVDase activation and processing of caspases and caspase substrates.
Chemical Information
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No. CAS 426834-38-0
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Appearance Solid
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Peso molecular 358.70
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Fòrmula C15H10ClF3N2O3
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Color Off-white to light yellow
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SMILES
O=C(O)C1=CC=C(Cl)C=C1NC(NC2=CC=CC(C(F)(F)F)=C2)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 250 mg/mL (696.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7878 mL | 13.9392 mL | 27.8784 mL | 69.6961 mL |
| 5 mM | 0.5576 mL | 2.7878 mL | 5.5757 mL | 13.9392 mL | |
| 10 mM | 0.2788 mL | 1.3939 mL | 2.7878 mL | 6.9696 mL | |
| 15 mM | 0.1859 mL | 0.9293 mL | 1.8586 mL | 4.6464 mL | |
| 20 mM | 0.1394 mL | 0.6970 mL | 1.3939 mL | 3.4848 mL | |
| 25 mM | 0.1115 mL | 0.5576 mL | 1.1151 mL | 2.7878 mL | |
| 30 mM | 0.0929 mL | 0.4646 mL | 0.9293 mL | 2.3232 mL | |
| 40 mM | 0.0697 mL | 0.3485 mL | 0.6970 mL | 1.7424 mL | |
| 50 mM | 0.0558 mL | 0.2788 mL | 0.5576 mL | 1.3939 mL | |
| 60 mM | 0.0465 mL | 0.2323 mL | 0.4646 mL | 1.1616 mL | |
| 80 mM | 0.0348 mL | 0.1742 mL | 0.3485 mL | 0.8712 mL | |
| 100 mM | 0.0279 mL | 0.1394 mL | 0.2788 mL | 0.6970 mL |
NS3694 Related Classifications
HY-108356 Related Classifications
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