NUCC-555
NUCC-555 is an activin antagonist. NUCC-555 interacts with Trp25, Trp28, Phe55, Tyr93, Lys103, and Asn107 in the Activin A binding pocket. NUCC-555 blocks Activin A-mediated hepatic stellate cells (HSCs) activation. NUCC-555 promotes liver regeneration and halts fibrosis progression in chronic liver disease models. NUCC-555 inhibits Activin A-mediated ovarian cell proliferation. NUCC-555 decreases FSH levels in ovariectomized mice.
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- No. CAS: 1060469-90-0
- Fòrmula: C25H25N5O3
- Peso molecular:443.50
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
12.1 μM
Compound: NUCC-555
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Induction of apoptosis in human HepG2 cells assessed as cell viability after 96 hrs by MTT assay
Induction of apoptosis in human HepG2 cells assessed as cell viability after 96 hrs by MTT assay
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[PMID: 26098096] |
Chemical Information
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No. CAS 1060469-90-0
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Peso molecular 443.50
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Fòrmula C25H25N5O3
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SMILES
O=C(NCC1=CC=CC=C1)C2=CC(NC(COC)=O)=CC3=C2N(C(C4=CC=CN=C4)=N3)CC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NUCC-555 Related Classifications
HY-122179 Related Classifications
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