OHM1
OHM1 is an analog of HIF1α CTAD that inhibits its binding with p300/CBP. OHM1 targets CH1 domain with an affinity of 0.53 μM.
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- No. CAS: 1450995-09-1
- Fòrmula: C24H42N6O5
- Peso molecular:494.63
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
OHM1 (1-20 μM; 24 h) results in a dose-dependent reduction in the HIF promoter activity, and reduces the level of HIF1α transcriptional activity under hypoxia to that observed under normoxia at 20 μM in MDA-MB-231 cells[1].
OHM1 down-regulates hypoxia-inducible gene expression[1].
OHM1 (10 μM) down-regulates multiple genes implicated in angiogenesis, apoptosis, cell proliferation, and invasion, along with several cancer-specific markers in the A549 non-small-cell lung cancer cell line[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549
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Concentration:10 μM
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Incubation Time:24 h
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Result:Down-regulated the mRNA expression levels of the critical angiogenesis regulator vascular endothelial growth factor (VEGFA) by 80%. Decreased lysyl oxidase (LOX) and glucose transporter 1 (GLUT1) expression.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c mice, MDA-MB-231 xenograft model[1]
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Dosage:15 mg/kg
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Administration:Intraperitoneal injection, every other day for 15 injections
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Result:Reduced the median tumor volume by roughly 50% compared with the untreated group. Did not cause measurable changes in animal body weight or other signs of toxicity in tumor-bearing animals, nor increased the metastasis rate.
Chemical Information
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No. CAS 1450995-09-1
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Peso molecular 494.63
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Fòrmula C24H42N6O5
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SMILES
O=C(N)[C@@H](N1C([C@H](C)N(C([C@@H](N2C([C@H](CC(C)C)NCC2)=O)CC(C)C)=O)CC1)=O)CCC(N)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
OHM1 Related Classifications
HY-124722 Related Classifications
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