OV329
OV329 is a potent GABA aminotransferase inactivator. OV329 is a Vigabatrin (HY-15399) analogue. OV329 can increase brain GABA levels and block abnormal intracerebral hyperexcitability. OV329 exhibits anticonvulsant and antiepileptic activities. OV329 can be used for the research of neurological disease, such as seizure.
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- No. CAS: 2093928-28-8
- Fòrmula: C7H7F2NO2
- Peso molecular:175.13
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
OV329 (30-40 mg/kg, i.p.) increases the afterdischarge threshold in amygdala-kindled rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Pentylenetetrazole-induced seizuring Wistar Unilever rats[1]
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Dosage:5, 20 and 40 mg/kg
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Administration:Intraperitoneally injection
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Result:Increased myoclonic seizure threshold from the 15.8 to 33.1 mg/kg at 40 mg/kg.
Increased clonic seizure threshold from the 19.5 to 40.98 mg/kg at 40 mg/kg.
Showed the EC50 for myoclonic seizures is 25.83 mg/kg and for clonic seizures is 20.8 mg/kg.
Showed the responder rate of rats reaches 100% at the dose of 40 mg/kg.
Chemical Information
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No. CAS 2093928-28-8
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Peso molecular 175.13
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Fòrmula C7H7F2NO2
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SMILES
N[C@H]1C=C(C/C1=C(F)/F)C(O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
OV329 Related Classifications
HY-179215A Related Classifications
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