OV329 hydrochloride
Based on 1 Customer Validation
OV329 hydrochloride is a potent GABA aminotransferase inactivator. OV329 hydrochloride is a Vigabatrin (HY-15399) analogue. OV329 hydrochloride can increase brain GABA levels and block abnormal intracerebral hyperexcitability. OV329 hydrochloride exhibits anticonvulsant and antiepileptic activities. OV329 hydrochloride can be used for the research of neurological disease, such as seizure.
For research use only. We do not sell to patients.
- Purity: 99.83%
- CAS No.: 2093928-29-9
- Formula: C7H8ClF2NO2
- Molecular Weight:211.59
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
OV329 hydrochloride (30-40 mg/kg, i.p.) increases the afterdischarge threshold in amygdala-kindled rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Pentylenetetrazole-induced seizuring Wistar Unilever rats[1]
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Dosage:5, 20 and 40 mg/kg
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Administration:Intraperitoneally injection
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Result:Increased myoclonic seizure threshold from the 15.8 to 33.1 mg/kg at 40 mg/kg.
Increased clonic seizure threshold from the 19.5 to 40.98 mg/kg at 40 mg/kg.
Showed the EC50 for myoclonic seizures is 25.83 mg/kg and for clonic seizures is 20.8 mg/kg.
Showed the responder rate of rats reaches 100% at the dose of 40 mg/kg.
Chemical Information
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CAS No. 2093928-29-9
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Appearance Powder
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Molecular Weight 211.59
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Formula C7H8ClF2NO2
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Color Off-white to light brown
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SMILES
N[C@H]1C=C(C/C1=C(F)\F)C(O)=O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)