OV329 hydrochloride

Name: OV329 hydrochloride
Brand: MedChemExpress
SKU: HY-179215
Rating: 4.5 (1 reviews)

Cat. No.: HY-179215 Purity: 99.83%: Data Sheet
COA

SDS
Handling Instructions
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OV329 hydrochloride is a potent GABA aminotransferase inactivator. OV329 hydrochloride is a Vigabatrin (HY-15399) analogue. OV329 hydrochloride can increase brain GABA levels and block abnormal intracerebral hyperexcitability. OV329 hydrochloride exhibits anticonvulsant and antiepileptic activities. OV329 hydrochloride can be used for the research of neurological disease, such as seizure.

For research use only. We do not sell to patients.

OV329 hydrochloride Chemical Structure

CAS No. : 2093928-29-9

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of OV329 hydrochloride:

OV329 Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vivo

OV329 hydrochloride (5-40 mg/kg, i.p.) shows anticonvulsant effect in pentylenetetrazole-induced seizuring rats^[1].
OV329 hydrochloride (30-40 mg/kg, i.p.) increases the afterdischarge threshold in amygdala-kindled rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Pentylenetetrazole-induced seizuring Wistar Unilever rats^[1]
Dosage:	5, 20 and 40 mg/kg
Administration:	Intraperitoneally injection
Result:	Increased myoclonic seizure threshold from the 15.8 to 33.1 mg/kg at 40 mg/kg. Increased clonic seizure threshold from the 19.5 to 40.98 mg/kg at 40 mg/kg. Showed the EC₅₀ for myoclonic seizures is 25.83 mg/kg and for clonic seizures is 20.8 mg/kg. Showed the responder rate of rats reaches 100% at the dose of 40 mg/kg.

Molecular Weight

211.59

Formula

C₇H₈ClF₂NO₂

CAS No.

2093928-29-9

Appearance

Powder

Color

Off-white to light brown

SMILES

N[C@H]1C=C(C/C1=C(F)\F)C(O)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: 99.83%

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Data Sheet (273 KB) SDS (252 KB)

COA (252 KB) HNMR (250 KB) RP-HPLC (206 KB) MS (68 KB)

Handling Instructions (2659 KB)

References

[1]. Feja M, et al. OV329, a novel highly potent γ-aminobutyric acid aminotransferase inactivator, induces pronounced anticonvulsant effects in the pentylenetetrazole seizure threshold test and in amygdala-kindled rats. Epilepsia. 2021 Dec;62(12):3091-3104. [Content Brief]