OX2-2303
OX2-2303 is a potent, selective orexin-2 receptor (OX2R) antagonist. OX2-2303 exhibits excellent binding affinity towards OX2R (Ki = 0.1 nM), and shows >890-fold selectivity over OX1R. OX2-2303 can be used as a positron emission tomography (PET) radioligand for central nervous system (CNS) research.
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- No. CAS: 1607428-33-0
- Fòrmula: C23H21FN4O2S
- Peso molecular:436.50
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Ver todos los productos específicos de isoformas Orexin Receptor (OX Receptor)
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
OX2 Receptor 0.1 nM (Ki) |
In Vitro
OX2-2303 (compound 1) exhibits no significant off-target activity across a panel of 59 major CNS targets, with exception of low affinity binding to sigma-2 (Ki = 2681 nM) and NR2B receptors (Ki = 9475 nM)[1].
OX2-2303 shows favorable tracer integrity, with no appreciable radiometabolites detected in saline, serum (mouse, rat, nonhuman primate, and human), and liver microsomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1607428-33-0
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Peso molecular 436.50
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Fòrmula C23H21FN4O2S
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SMILES
FC1=CC(C(N2C[C@H](OC3=NC=CC(C#N)=C3C)CC[C@H]2C)=O)=C(C4=NC=CS4)C=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
OX2-2303 Related Classifications
HY-178871 Related Classifications
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