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Referencia número: HY-P12013

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PEG12KL4

PEG12KL4 is a PEG-modified amphipathic cell-penetrating peptide. PEG12KL4 promotes the transfection and delivery of mRNA into lung cells, maintains mRNA stability, and forms mRNA complexes that retain integrity and translatability. PEG12KL4 endows lipid nanoparticles (LNPs) with anti-nebulization properties, enhances transfection efficiency in artificial mucus when used in combination with LNPs, and enables the formation of dry powder formulations with low toxicity and mild inflammatory responses. PEG12KL4 can be used in studies related to drug delivery for pulmonary diseases (cystic fibrosis, chronic obstructive pulmonary disease).

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₁₅₃H₂₉₁N₂₇O₃₅
Peso molecular:3069.11

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

PEG12KL4 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

In Vitro

PEG12KL4 (1.5-40 mol%; at least 30 min)-containing LNPs with 10 mol% PEG12KL4 (P10NP3) maintain stable hydrodynamic size, polydispersity index, zeta potential, and encapsulation efficiency following nebulisation^[1].
PEG12KL4-containing LNPs with 10 mol% PEG12KL4 (P10NP3) maintain consistent mRNA transfection efficiency in A549 cells following nebulisation^[1].
PEG12KL4 forms stable mRNA complexes that can be processed into dry powder aerosols via spray drying and spray freeze drying while preserving mRNA integrity and translational capability^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Peso molecular 3069.11
Fòrmula C₁₅₃H₂₉₁N₂₇O₃₅
SMILES

O=C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)NC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)=O
Sequence

PEG12-Lys-Leu-Leu-Leu-Leu-Lys-Leu-Leu-Leu-Leu-Lys-Leu-Leu-Leu-Leu-Lys-Leu-Leu-Leu-Leu-Lys-NH2
Sequence Shortening

PEG12-KLLLLKLLLLKLLLLKLLLLK-NH2
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Ma C. The combination of PEG12KL4 peptide and lipid nanoparticles (LNPs) for pulmonary mRNA delivery via nebulisation. DDL2025, 2025.

[2]. Yokoo H, et al. Cell-Penetrating Peptides: Emerging Tools for mRNA Delivery. Pharmaceutics. 2021 Dec 29;14(1):78. [Content Brief]

[3]. He X, et al. Nonviral targeted mRNA delivery: principles, progresses, and challenges. MedComm. 2025 Jan;6(1):e70035. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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