Pentetreotide
Based on 1 Customer Validation
Pentetreotide is a diethylenetriaminopentaacetic (DTPA) conjugate of Octreotide (HY-P0036). Pentetreotide is a somatostatin analog that, when labeled with 111In, can be used for nuclear medicine imaging. Somatostatin receptor scintigraphy with Pentetreotide is effective in visualizing neuroendocrine tumors, and its metastasis.
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- Pureza: 98.13%
- No. CAS: 138661-02-6
- Fòrmula: C63H87N13O19S2
- Peso molecular:1394.57
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Almacenamiento:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Ver todos los productos específicos de isoformas Radionuclide-Drug Conjugates (RDCs)
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Actividad biológica
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RDC Peptide |
Neuroendocrine tumors have an increased number of somatostatin receptors, as compared to normal tissues. At present time, there are five known subtypes. Somatostatin receptor scintigraphy with 111In-Pentetreotide binds to two of these subtypes and is effective in visualizing neuroendocrine tumors, and its metastasis with an overall diagnostic sensitivity of 70% to 90%. It is considerably more sensitive than conventional anatomic imaging. Its usage in neuroendocrine tumors not only includes assessment of disease extent, but also in identified primary lesion, assesses treatment response, and selection for radionuclide therapy[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 138661-02-6
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Appearance Solid
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Peso molecular 1394.57
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Fòrmula C63H87N13O19S2
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Color White to off-white
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Sequence
DTPA-{d-Phe}-Cys-Phe-{d-Trp}-Lys-Thr-Cys-{Threoninol} (Disulfide bridge:Cys3-Cys8)
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Sequence Shortening
DTPA-{d-Phe}-CF-{d-Trp}-KTC-{Threoninol} (Disulfide bridge:Cys3-Cys8)
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvente y solubilidad
DMSO : 100 mg/mL (71.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (278 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Portuguese - PT (254 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Al-Suqri B. 111 In-pentetreotide SPECT CT Value in Follow-up of Patients with Neuro-Endocrine Tumors. Oman Med J. 2014 Sep;29(5):362-4. [Content Brief]
[2]. Masuda R, et al. Concise site-specific synthesis of DTPA-peptide conjugates: application to imaging probes for the chemokine receptor CXCR4. Bioorg Med Chem. 2011 May 15;19(10):3216-20. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.7171 mL | 3.5853 mL | 7.1707 mL | 17.9267 mL |
| 5 mM | 0.1434 mL | 0.7171 mL | 1.4341 mL | 3.5853 mL | |
| 10 mM | 0.0717 mL | 0.3585 mL | 0.7171 mL | 1.7927 mL | |
| 15 mM | 0.0478 mL | 0.2390 mL | 0.4780 mL | 1.1951 mL | |
| 20 mM | 0.0359 mL | 0.1793 mL | 0.3585 mL | 0.8963 mL | |
| 25 mM | 0.0287 mL | 0.1434 mL | 0.2868 mL | 0.7171 mL | |
| 30 mM | 0.0239 mL | 0.1195 mL | 0.2390 mL | 0.5976 mL | |
| 40 mM | 0.0179 mL | 0.0896 mL | 0.1793 mL | 0.4482 mL | |
| 50 mM | 0.0143 mL | 0.0717 mL | 0.1434 mL | 0.3585 mL | |
| 60 mM | 0.0120 mL | 0.0598 mL | 0.1195 mL | 0.2988 mL |
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