PF-03049423
PF-03049423 (Compound PF-5) is a potent and highly selective phosphodiesterase-5A inhibitor with an IC50 of about 0.2 nM for rat and human platelet enzyme. PF-03049423 can be used for the research of acute ischaemic stroke.
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- No. CAS: 402955-58-2
- Fòrmula: C24H32N6O4.xHCl
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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PDE5A |
rat and human platelet enzyme ~0.2 nM (IC50) |
PF-03049423 (1.0 mg/kg b.i.d. or 0.6 mg/kg q.d. for 7 days) improves poststroke sensory–motor behavioral outcome even when the treatment is initiated 24-72 hours after occlusion[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats, middle cerebral artery occlusion (MCA-o) model[1]
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Dosage:0.1, 1, or 10 mg/kg
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Administration:Subcutaneous injection, b.i.d. for 7 days
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Result:Improved functional recovery at 1 mg/kg and 10 mg/kg.
Chemical Information
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No. CAS 402955-58-2
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Fòrmula C24H32N6O4.xHCl
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SMILES
O=C1C(N2CCN(CC2)CCO)=NC3=C(N1CCOCCC)C=C(C4=CC=C(OC)N=C4)N=C3.[x HCl]
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PF-03049423 Related Classifications
HY-10679A Related Classifications
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