Pimivalimab
Based on 1 Customer Validation
Pimivalimab (JTX-4014) is an anti-PD-1 IgG4 monoclonal antibody. Pimivalimab binds to PD-1, blocking its interaction with PD-L1 and PD-L2, and enhances antitumor immune activity. Pimivalimab can be used for research on advanced or metastatic renal cell carcinoma and metastatic non-small cell lung cancer.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 2293951-22-9
- Peso molecular:144.9 kDa
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Almacenamiento:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
Actividad biológica
Descripciòn
Isotype
Human IgG4 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
PDCD1/PD-1/CD279
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconstitution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG4 kappa
Aplicación
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized PD-1 Protein, Human (143a.a, HEK293, His, HY-P7396) can bind Pimivalimab. The EC50 for this effect is 4.21 ng/mL.
Chemical Information
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No. CAS 2293951-22-9
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Appearance Liquid
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Peso molecular 144.9 kDa
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Color Colorless to light yellow
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SMILES
[Pimivalimab]
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Synonyms
JTX-4014
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Envío
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
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Ficha de datos (267 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)