Pralidoxime iodide
Based on 1 Customer Validation
Pralidoxime iodide is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning.
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- Pureza: 98.0%
- No. CAS: 94-63-3
- Fòrmula: C7H9IN2O
- Peso molecular:264.06
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Almacenamiento:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Actividad biológica
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AChE |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male F1B6D2 mice (toxic but non-lethal model of diethylparaoxon in awake, unrestrained mice)[3]
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Dosage:10, 50, 100 and 150 mg/kg
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Administration:Intramuscularly, once
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Result:Induced a partial, albeit complete, reversal of respiratory toxicity at 50 mg/kg, and completely reversed diethylparaoxon-induced respiratory toxicity in mice at 150 mg/kg.
Chemical Information
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No. CAS 94-63-3
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Appearance Solid
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Peso molecular 264.06
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Fòrmula C7H9IN2O
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Color Light yellow to yellow
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SMILES
C[N+]1=CC=CC=C1/C=N/O.[I-]
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvente y solubilidad
DMSO : 250 mg/mL (946.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Cadieux CL, et al. Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents. Chem Biol Interact. 2016;259(Pt B):133‐141. [Content Brief]
[2]. Eyer P, Buckley N. Pralidoxime for organophosphate poisoning. Lancet. 2006;368(9553):2110‐2111. [Content Brief]
[3]. Houzé P, et al. High Dose of Pralidoxime Reverses Paraoxon-Induced Respiratory Toxicity in Mice. Turk J Anaesthesiol Reanim. 2018;46(2):131‐138. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7870 mL | 18.9351 mL | 37.8702 mL | 94.6755 mL |
| 5 mM | 0.7574 mL | 3.7870 mL | 7.5740 mL | 18.9351 mL | |
| 10 mM | 0.3787 mL | 1.8935 mL | 3.7870 mL | 9.4675 mL | |
| 15 mM | 0.2525 mL | 1.2623 mL | 2.5247 mL | 6.3117 mL | |
| 20 mM | 0.1894 mL | 0.9468 mL | 1.8935 mL | 4.7338 mL | |
| 25 mM | 0.1515 mL | 0.7574 mL | 1.5148 mL | 3.7870 mL | |
| 30 mM | 0.1262 mL | 0.6312 mL | 1.2623 mL | 3.1558 mL | |
| 40 mM | 0.0947 mL | 0.4734 mL | 0.9468 mL | 2.3669 mL | |
| 50 mM | 0.0757 mL | 0.3787 mL | 0.7574 mL | 1.8935 mL | |
| 60 mM | 0.0631 mL | 0.3156 mL | 0.6312 mL | 1.5779 mL | |
| 80 mM | 0.0473 mL | 0.2367 mL | 0.4734 mL | 1.1834 mL | |
| 100 mM | 0.0379 mL | 0.1894 mL | 0.3787 mL | 0.9468 mL |
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