Progoitrin potassium
Progoitrin potassium is an orally active glucosinolate. As the precursor of goitrin (HY-N0224A), an antithyroid compound, progoitrin releases goitrin via hydrolysis by myrosinase or gastrointestinal glucosidase. Progoitrin converts to goitrin in vivo and exerts antithyroid activity by inhibiting the accumulation of radioactive iodine in the thyroid gland. Progoitrin potassium can be used in the research of Graves' disease (thyrotoxicosis).
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- No. CAS: 21087-77-4
- Fòrmula: C11H18KNO10S2
- Peso molecular:427.49
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
In Vitro
Potassium progoitrin (1.4 μmol/g; 5-60 min at 150-200 °C) shows the lowest thermal stability in pH 9.0 phosphate buffer and undergoes thermal degradation to produce volatile flavor compounds[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Holtzman rats (male, 100-120 gm)[3]
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Dosage:20 mg; 200 mg; 300 mg; 625 mg; 1000 mg
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Administration:p.o.; s.c.; i.p.; 1 to 23.5 hours before I131 injection
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Result:Reduced thyroidal I131 uptake.
Chemical Information
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No. CAS 21087-77-4
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Peso molecular 427.49
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Fòrmula C11H18KNO10S2
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SMILES
C=C[C@H](O)C/C(S[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO)=N/OS(=O)(O[K])=O
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[2]. Collett MG, et al. Hepatotoxicity of Two Progoitrin-Derived Nitriles in New Zealand White Rabbits. Toxins. 2020 Nov 02;12(11):695. [Content Brief]
[3]. GREER MA, et al. Antithyroid activity elicited by the ingestion of pure progoitrin, a naturally occurring thioglycoside of the turnip family. J Clin Invest. 1959 Sep;38(9):1465-74. [Content Brief]
[4]. Liu Z, et al. Reducing progoitrin and enriching glucoraphanin in Brassica napus seeds through silencing of the GSL-ALK gene family. Plant molecular biology. 2012 May;79(1-2):179-89. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Progoitrin potassium Related Classifications
HY-N10348A Related Classifications
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