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Referencia número: HY-184893

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PSH18

PSH18 is a selective monoamine oxidase B (MAO-B) inhibitor with blood-brain barrier permeability, with a human-derived IC₅₀ of 0.95 μM and a K_i of 0.89 μM. PSH18 can be used for the research of Parkinson's disease.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₁₈H₁₃FN₄OS
Peso molecular:352.39

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

PSH18 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

hMAO-B

0.95 μM (IC₅₀)

hMAO-B

0.89 μM (Ki)

Ver todos los productos específicos de isoformas Monoamine Oxidase :

MAO-A
MAO-B

In Vitro

PSH18 competes with substrates for binding to the active site of MAO-B, and forms stable active site interactions through hydrophobic interactions and π-π stacking^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Peso molecular 352.39
Fòrmula C₁₈H₁₃FN₄OS
SMILES

S=C(N/N=C1C(N(CC#C)C2=C\1C=C(F)C=C2)=O)NC3=CC=CC=C3
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Parmbil SK, et al. Synthesis, biological evaluation and in silico studies of novel propargyl-tethered isatin hydrazones as monoamine oxidase inhibitors for Parkinson's disease. Scientific reports. 2026 Jun 19. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias

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PSH18

Ver todos los productos específicos de isoformas Monoamine Oxidase