QD394
Based on 2 publication(s) in Google Scholar
QD394 is a reactive oxygen species (ROS) inducer that can induce lipid peroxidation, increase intracellular ROS accumulation, inhibit STAT3 phosphorylation, and induce ferroptosis.
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- Pureza: 99.69%
- No. CAS: 2132411-21-1
- Fòrmula: C19H19N5O2
- Peso molecular:349.39
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Almacenamiento:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Publications Citing Use of MedChemExpress (MCE) QD394
More
Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BXPC-3 | IC50 |
0.9 μM
Compound: QD394
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Cytotoxicity against human BXPC-3 cells measured after 72 hrs by MTT assay
Cytotoxicity against human BXPC-3 cells measured after 72 hrs by MTT assay
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[PMID: 32809827] |
| MIA PaCa-2 | IC50 |
0.53 μM
Compound: QD394
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Cytotoxicity against human MIA PaCa-2 cells measured after 72 hrs by MTT assay
Cytotoxicity against human MIA PaCa-2 cells measured after 72 hrs by MTT assay
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[PMID: 32809827] |
| MIA PaCa-2 | IC50 |
1.11 μM
Compound: QD394
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Cytotoxicity against human MIA PaCa-2 cells measured after 72 hrs in presence of N-acetylcysteine by MTT assay
Cytotoxicity against human MIA PaCa-2 cells measured after 72 hrs in presence of N-acetylcysteine by MTT assay
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[PMID: 32809827] |
| PANC-1 | IC50 |
0.34 μM
Compound: QD394
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Cytotoxicity against human PANC-1 cells measured after 72 hrs by MTT assay
Cytotoxicity against human PANC-1 cells measured after 72 hrs by MTT assay
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[PMID: 32809827] |
QD394 (0-10 μM, 24 h) is cytotoxic with the IC50 values of 0.64, 0.34 and 0.9 μM for MIA PaCa-2, PANC-1 and BxPC-3 cell lines, respectively. And QD394 can inhibit the phosphorylation of STAT3 in cells and increase the phosphorylation of H2AX[1].
QD394(1-10 μM, 4 h) mediates cell death by increasing cellular ROS levels and decreases GSH/GSSG ratio in MIA PaCa-2 cells; also induces iron-dependent and GPX4-mediated ferroptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2132411-21-1
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Appearance Solid
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Peso molecular 349.39
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Fòrmula C19H19N5O2
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Color Dark purple to black
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SMILES
O=C1C=C(C(C2=C1N=CN=C2)=O)NC3=CC=C(N4CCN(CC4)C)C=C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Apoptosis
QD394 induces ferroptosis and suppresses the proliferation of colorectal cancer via the SP1/JNK pathway. [Abstract]2026 May 6;31(5):133. PMID: 42090009 -
Immun Inflamm Dis
Liver X Receptor Activation Alleviates Hepatic Ischemia-Reperfusion Injury in Diabetes by Inhibiting NF-κB-NLRP3 Activation. [Abstract]2025 Aug;13(8):e70243. PMID: 40778489
Solvente y solubilidad
DMSO : 7.33 mg/mL (20.98 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 0.73 mg/mL (2.09 mM); Clear solution
This protocol yields a clear solution of ≥ 0.73 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (7.3 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 0.73 mg/mL (2.09 mM); Clear solution
This protocol yields a clear solution of ≥ 0.73 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (7.3 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8621 mL | 14.3107 mL | 28.6213 mL | 71.5533 mL |
| 5 mM | 0.5724 mL | 2.8621 mL | 5.7243 mL | 14.3107 mL | |
| 10 mM | 0.2862 mL | 1.4311 mL | 2.8621 mL | 7.1553 mL | |
| 15 mM | 0.1908 mL | 0.9540 mL | 1.9081 mL | 4.7702 mL | |
| 20 mM | 0.1431 mL | 0.7155 mL | 1.4311 mL | 3.5777 mL |
QD394 Related Classifications
HY-139369 Related Classifications
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