RA375
Based on 1 Customer Validation
RA375 is a RPN13 (26S proteasome regulatory subunit) inhibitor. RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater activity against cancer lines than RA190, reflecting its nitro ring substituents and the addition of a chloroacetamide warhead.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.87%
- No. CAS: 2649154-57-2
- Fòrmula: C30H25ClN4O7
- Peso molecular:589.00
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Immunology/Inflammation Compound Library
HY-L007
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Metabolism/Protease Compound Library
HY-L012
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NF-κB Signaling Compound Library
HY-L014
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Ubiquitination Compound Library
HY-L050
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Anti-Blood Cancer Compound Library
HY-L079
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Heterocyclic Compound Library
HY-L138
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Protease Inhibitor Library
HY-L147
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Cell Death Library
HY-L162
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Anti-Hematopathy Compound Library
HY-L171
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
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Lactylation Compound Library
HY-L249
Actividad biológica
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:RA375 (10 mg/kg, ip) inhibits proteasome function and reduces ovarian tumor burden in mice[1].
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Dosage:10 mg/kg.
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Administration:IP for a 5 days on, 2 days off cycle for two weeks.
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Result:Reduced ovarian tumor burden in mice.
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Animal Model:Female Balb/c mice[1].
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Dosage:5, 10, 20, 40, 60, 100 mg/kg (Pharmacological Analysis).
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Administration:IP single dose.
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Result:The dose of 40 mg/kg on alternate days for two weeks produced no observable toxicities or weight loss.
Chemical Information
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No. CAS 2649154-57-2
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Appearance Solid
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Peso molecular 589.00
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Fòrmula C30H25ClN4O7
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Color Light yellow to yellow
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SMILES
O=C([C@@H](NC(CCl)=O)CC1=CC=CC=C1)N(C/C(C/2=O)=C\C3=CC=C([N+]([O-])=O)C=C3)CC2=C/C4=CC=C([N+]([O-])=O)C=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 100 mg/mL (169.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6978 mL | 8.4890 mL | 16.9779 mL | 42.4448 mL |
| 5 mM | 0.3396 mL | 1.6978 mL | 3.3956 mL | 8.4890 mL | |
| 10 mM | 0.1698 mL | 0.8489 mL | 1.6978 mL | 4.2445 mL | |
| 15 mM | 0.1132 mL | 0.5659 mL | 1.1319 mL | 2.8297 mL | |
| 20 mM | 0.0849 mL | 0.4244 mL | 0.8489 mL | 2.1222 mL | |
| 25 mM | 0.0679 mL | 0.3396 mL | 0.6791 mL | 1.6978 mL | |
| 30 mM | 0.0566 mL | 0.2830 mL | 0.5659 mL | 1.4148 mL | |
| 40 mM | 0.0424 mL | 0.2122 mL | 0.4244 mL | 1.0611 mL | |
| 50 mM | 0.0340 mL | 0.1698 mL | 0.3396 mL | 0.8489 mL | |
| 60 mM | 0.0283 mL | 0.1415 mL | 0.2830 mL | 0.7074 mL | |
| 80 mM | 0.0212 mL | 0.1061 mL | 0.2122 mL | 0.5306 mL | |
| 100 mM | 0.0170 mL | 0.0849 mL | 0.1698 mL | 0.4244 mL |
RA375 Related Classifications
HY-136563 Related Classifications
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