RM-041

RM-041 is a selective, orally active KRAS^G13C (ON) inhibitor that forms a covalent complex with KRAS^G13C (ON) and Cyclophilin A. RM-041 blocks the binding of RAS effector proteins via steric hindrance, and then covalently binds to Cys-13 to form an irreversible inhibitory complex, thereby inhibiting the proliferation of KRAS^G13C mutant cancer cells. RM-041 induces regression of KRAS^G13C tumors in cellular and xenograft tumor models. RM-041 exerts a synergistic effect when combined with upstream node inhibitors (such as SHP2 inhibitors). RM-041 can be used for the research of non-small cell lung cancer.

• Data Sheet (274 KB)