RTC13
Based on 1 Customer Validation
RTC13 restores dystrophin expression and improves muscle function in the mdx mouse model for Duchenne muscular dystrophy (DMD).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.01%
- No. CAS: 1359825-94-7
- Fòrmula: C14H9N3O4S
- Peso molecular:315.30
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | GI50 |
>80 μM
Compound: 3
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Antiproliferative activity against HCT116 cells by SRB assay after 72 hrs
Antiproliferative activity against HCT116 cells by SRB assay after 72 hrs
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[PMID: 17570665] |
In Vivo
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Animal Model:Wild-type (C57BL/10) mice at 10 to 12 weeks of age[1].
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Dosage:10 (n = 5), 30 (n = 5), 60 (n = 5) or 300 mg/kg (n = 5).
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Administration:Intraperitoneal Administration.
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Result:No changes were observed in liver and kidney weights at the time of necropsies, and Hematoxylin and Eosin (H&E) staining revealed the absence of histopathological changes.
Chemical Information
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No. CAS 1359825-94-7
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Appearance Solid
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Peso molecular 315.30
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Fòrmula C14H9N3O4S
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Color Orange to red
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SMILES
O=[N+](C1=C(C=CC=C1)C2=CC=C(/C=C3C(NC(S/3)=N)=O)O2)[O-]
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 100 mg/mL (317.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 20% Solutol HS-15 70% Saline
Solubility: 6.25 mg/mL (19.82 mM); Suspended solution; Need ultrasonic
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 50% PEG300 50% Saline
Solubility: 5 mg/mL (15.86 mM); Suspended solution; Need ultrasonic
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.1716 mL | 15.8579 mL | 31.7158 mL | 79.2896 mL |
| 5 mM | 0.6343 mL | 3.1716 mL | 6.3432 mL | 15.8579 mL | |
| 10 mM | 0.3172 mL | 1.5858 mL | 3.1716 mL | 7.9290 mL | |
| 15 mM | 0.2114 mL | 1.0572 mL | 2.1144 mL | 5.2860 mL | |
| 20 mM | 0.1586 mL | 0.7929 mL | 1.5858 mL | 3.9645 mL | |
| 25 mM | 0.1269 mL | 0.6343 mL | 1.2686 mL | 3.1716 mL | |
| 30 mM | 0.1057 mL | 0.5286 mL | 1.0572 mL | 2.6430 mL | |
| 40 mM | 0.0793 mL | 0.3964 mL | 0.7929 mL | 1.9822 mL | |
| 50 mM | 0.0634 mL | 0.3172 mL | 0.6343 mL | 1.5858 mL | |
| 60 mM | 0.0529 mL | 0.2643 mL | 0.5286 mL | 1.3215 mL | |
| 80 mM | 0.0396 mL | 0.1982 mL | 0.3964 mL | 0.9911 mL | |
| 100 mM | 0.0317 mL | 0.1586 mL | 0.3172 mL | 0.7929 mL |
RTC13 Related Classifications
HY-101459 Related Classifications
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