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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2438 Results for "
decrease
" in MedChemExpress (MCE) Product Catalog:
Products (2438)
2438 Results for "decrease" in MCE Product Catalog:
Referencia número: HY-101630A
No. CAS: 120444-72-6
Synonyms: EGIS-3886 fumarate
Target:
Áreas de investigación:
Deramciclane fumarate is an antagonist of 5-HT Receptor. Deramciclane fumarate is an inverse agonist of 5-HT2C Receptor with an IC50 of 168 nM. Deramciclane fumarate also decreases basal phosphoinositide hydrolysis .
Referencia número: HY-114567
No. CAS: 1093294-48-4
Target:
Áreas de investigación:
GW780056X is a CDK12 inhibitor. GW780056X decreases nuclear foci count in DM1 cells. GW780056X can be used for the research of myotonic dystrophy type 1 .
Target:
Áreas de investigación:
Propanidid (Sombrevin; Fabantol) is a γ-aminobutyric acid type A (GABAA) receptor agonist and a short-acting non-barbiturate general agent that can suppress or relieve pain. Propanidid can decrease the arterial pressure .
justicidin A is a nature product that could be isolated form Justicia procumbens. justicidin A decreases the level of Ku70 leading to translocation of Bax from the cytosol to mitochondria to induce apoptosis. justicidin A can be used in research of cancer .
Target:
Áreas de investigación:
IND24 is a potent antiprion agent with an EC50 value of 1.27 µM. IND24 decreases abnormal, misfolded, pathogenic forms of benign normally occurring prion protein on the cell surface or inside the cell .
Target:
Áreas de investigación:
ORM-10103 is a specific inhibitor of the Na+/Ca2+ exchanger (NCX), which decreases the NCX current with estimated IC50s of 55 and 67 nM at -80 and at 20 mV, respectively .
Referencia número: HY-135375
No. CAS: 887196-29-4
Target:
Áreas de investigación:
O-Methyl Atorvastatin (hemicalcium) is an impurity of Atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids .
Referencia número: HY-136185
No. CAS: 873950-19-7
Target:
Áreas de investigación:
Atorvastatin Epoxy Tetrahydrofuran Impurity is an impurity isolated oxidative degradation products of Atorvastatin (HY-B0589) . Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids.
Referencia número: HY-145873
No. CAS: 2759037-58-4
BI-10 is an antifungal compound. BI-10 combined with Fluconazole can inhibit hyphal growth, result in ROS accumulation, and decrease mitochondrial membrane potential (MMP) as well as altering membrane permeability .
Referencia número: HY-14747
No. CAS: 625114-41-2
Synonyms: RO4389620; R-1440
Target:
Áreas de investigación:
Piragliatin (RO4389620) is an activator for glucokinase, which reduces endogenous glucose production, increases β-cell function and glucose utilization, and thus decreases the blood glucose levels. Piragliatin exhibits antidiabetic efficacy .
Referencia número: HY-154387
No. CAS: 1219485-46-7
Synonyms: 1-IsoPT
Áreas de investigación:
1-Isopropyltryptophan (1-IsoPT) is a IDO1 inhibitor. 1-Isopropyltryptophan decreases the expression of IFN-γ stimulated ID0-1 and ID0-2 mRNA .
Referencia número: HY-178853
No. CAS: 87112-04-7
Target:
Áreas de investigación:
3,4-Dihydroxybenzeneethanimidamide can selectively react with Gly-Pro, the substrate for prolidase, and the prolidase activity is measured by monitoring the decrease in FL intensities. 3,4-Dihydroxybenzeneethanimidamide can be used for the study of inflammation .
Referencia número: HY-N0465S
No. CAS: 1189487-82-8
Referencia número: HY-N10772
No. CAS: 73343-42-7
Referencia número: HY-N3009R
No. CAS: 58822-47-2
Target:
Referencia número: HY-P4497
No. CAS: 71835-80-8
Referencia número: HY-114913
No. CAS: 60168-88-9
Synonyms: EL 222
Target:
Áreas de investigación:
Fenarimol (EL 222) is a potent and orally active fungicide. Fenarimol also is a androgen receptor inhibitor with an IC50 value of 19 µM. Fenarimol decreases the mRNA expression of PBP C3, ODC, IGF-1 .
Referencia número: HY-124863A
No. CAS: 241476-71-1
Target:
Áreas de investigación:
(R)-AAL is an immunomodulator. (R)-AAL decreases circulating T lymphocytes in rats, with an ID50 value of 0.009 mg/kg. (R)-AAL is a substrate of sphingosine kinase (SphK), which catalyzes the phosphorylation of (R)-AAL .
Target:
Áreas de investigación:
Clorprenaline is a potent agonist of β2-adrenergic. Clorprenaline promotes animal muscular mass growth and decreases fat accumulation. Clorprenaline is a potential new lean meat-boosting feed additive .
Referencia número: HY-150192
No. CAS: 21489-20-3
Target:
Áreas de investigación:
Talsupram is a selective noradrenaline inhibitor that has a high affinity for the noradrenaline transporter. Talsupram exhibits anti-hyperalgesic effects. Talsupram can decrease ethanol intake to the levels prior to REM-induced deprivation in rat model .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
