2438 Results for "

decrease

" in MedChemExpress (MCE) Product Catalog:
Products (2438)

2438 Results for "decrease" in MCE Product Catalog:

Referencia número: HY-B0185AS1
No. CAS: 2517378-96-8
Synonyms: Lignocaine-d6 hydrochloride
Lidocaine-d6 (hydrochloride) is deuterium labeled Lidocaine (hydrochloride). Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence . Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride is an amide derivative and a agent to treat ventricular arrhythmia and an effective tumor-inhibitor .
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Referencia número: HY-B0185S
No. CAS: 851528-10-4
N-Oxide Lidocaine-d10 is the deuterium labeled Lidocaine. Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence . Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia .
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Referencia número: HY-B0557R
No. CAS: 603-50-9
Bisacodyl (Standard) is the analytical standard of Bisacodyl. This product is intended for research and analytical applications. Bisacodyl is a stimulant laxative agent that works directly on the colon to produce a bowel movement. Bisacodyl increases the secretion of PGE2 by direct activation of colon macrophages. PGE2 acts as a paracrine factor and decreases the expression of AQP3 in the colon, which inhibits water transfer from the luminal to the vascular side and leads to a laxative effect .
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Referencia número: HY-B1202A
No. CAS: 51876-97-2
Synonyms: AY-22284A
Target:  

Aldose Reductase

Áreas de investigación:  

Metabolic Disease

Alrestatin (AY-22284) sodium is an aldose reductase inhibitor. Alrestatin sodium reduces fructose levels in the uterine fluid of mice. Alrestatin sodium interferes with sperm capacitation and impairs fertilization function in mice. Alrestatin sodium decreases basal and tyramine-induced norepinephrine release in rat pancreatic specimens in vitro. Alrestatin sodium enhances glucose- and arginine-stimulated insulin secretion in vivo. Alrestatin sodium can be used in studies related to diabetes and reproductive diseases .
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Referencia número: HY-B1452S1
No. CAS: 1178549-81-9
Synonyms: ML-3000-d6
Licofelone-d6 is the deuterium labeled Licofelone . Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC50=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins .
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Referencia número: HY-N1366R
No. CAS: 531-59-9
Synonyms: Methylumbelliferone (Standard)
Herniarin (Standard) (Methylumbelliferone (Standard)) is the analytical standard of Herniarin (HY-N1366). This product is intended for research and analytical applications. Herniarin is a natural coumarin occurs in some flowering plants with anticancer effects. Herniarin results in a significant decrease in cell viability by inducing apoptosis in MCF-7 cells. Herniarin also has anti-dermatophytic activity. Herniarin can be used for the study of bladder cancer and breast cancer.
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Referencia número: HY-N21955
No. CAS: 96657-94-2
Merenskine is a chlorinated 1,2-unsaturated senecionine-type pyrrolizidine alkaloid and serves as a substrate for epoxidation reactions. Merenskine forms merepoxine N-oxide upon evaporation in ammoniated solvents, while it generates merepoxine under alkaline sample preparation conditions. Merenskine exhibits a pH-dependent transfer rate in black tea infusion, and the transfer rate decreases sharply under alkaline conditions .
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Referencia número: HY-N4192
No. CAS: 1329-10-8
Toringin, a bioflavonoid, is isolated from the bark of Docyniopsis tschonoski. Toringin progressively decreases not only the cis-effect of the expanded CTG repeats but cytotoxicity as well. Exposure to isosakuranetin, Toringin rescues PC12 neuronal cells. Flavonoids are efficacious for ameliorating the RNA gain of function caused by expanded CTG repeats, and have various biological activities and beneficial actions against cancers, coronary heart disease, among other pathologies .
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Referencia número: HY-N6838
No. CAS: 62512-19-0
Synonyms: 1,1,1,1-Kestohexose
1,1,1,1-Kestohexaose (1,1,1,1-Kestohexose) is an insulin-type fructooligosaccharide hexasaccharide. 1,1,1,1-Kestohexaose exhibits neuroprotective and anti-depressant-like activities. 1,1,1,1-Kestohexaose can alleviate Corticosteron (HY-B1618)-induced decrease in cell viability and NGF expression in vitro .
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Referencia número: HY-P0083A
No. CAS: 914453-98-8
Synonyms: POR-8 acetate
Target:  

Vasopressin Receptor

Áreas de investigación:  

Cardiovascular Disease

Ornipressin (POR-8) acetate is a potent vasoconstrictor, hemostatic and renal agent. Ornipressin acetate is a vasopressin agonist specific for the V1 receptor. Ornipressin acetate can be used as a local vasoconstrictor. Ornipressin acetate can reverse the hypotension associated with combine general/epidural anesthesia. Ornipressin acetate has antidiuretic activity. Ornipressin acetate decreases renal vascular resistance and increases renal blood flow in renal failure model .
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Referencia número: HY-P11736
No. CAS: 1489241-80-6
Target:  

NF-κB

Áreas de investigación:  

Metabolic Disease

mcIRBP-9 is an orally active NF-κB inhibitor. mcIRBP-9 reduces the levels of TNF-α, IL-1β and TGF-β1 in renal tissues, and decreases LPS-induced IL-1β production. mcIRBP-9 can be used in research related to diabetic nephropathy and type 2 diabetes mellitus .
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Referencia número: HY-P1201A
Áreas de investigación:  

Inflammation/Immunology Cancer

Cyclosomatostatin TFA is a non-selective somatostatin receptor antagonist that blocks SSTR1-5-mediated signaling. Cyclosomatostatin TFA decreases the ALDH + stem cell population and sphere formation without affecting cell viability, and reduces cell proliferation. Cyclosomatostatin TFA activates opioid receptors. Cyclosomatostatin TFA can be used for research on arthritis and colorectal cancer .
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Referencia número: HY-P12363
Áreas de investigación:  

Neurological Disease

MyomP1 peptide is a functionalized modification group targeting apolipoprotein E (ApoE). MyomP1 peptide restricts the adsorption of ApoE on lipid nanoparticles, reduces ApoE-mediated hepatic uptake, and confers liver detargeting. MyomP1 peptide attenuates innate immune activation by reducing the expression of inflammatory markers and decreasing macrophage recruitment at the injection site. MyomP1 peptide is useful for research on rare muscle diseases .
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Referencia número: HY-P5490
No. CAS: 1370290-59-7
Synonyms: NPQ 53-70
Target:  

Inhibitory Antibodies

Áreas de investigación:  

Others

Spexin-2 (53-70), human,mouse,rat (NPQ 53-70) is a biological active peptide. (This is Spexin-2 (53-70), non-amidated version of the novel peptide hormone that is derived from prohormone proNPQ and is conserved amongst mammalian species. It is a central modulator of cardiovascular and renal function. Spexin-2, when administered to rats, decreases heart rate and increases urine flow rate)
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Referencia número: HY-W007894R
No. CAS: 595-46-0
Synonyms: Dimethylpropanedioic acid (Standard)
Dimethylmalonic acid (Standard) (Dimethylpropanedioic acid (Standard)) is the analytical standard of Dimethylmalonic acid (HY-W007894). This product is intended for research and analytical applications. Dimethylmalonic acid (Dimethylpropanedioic acid) is a succinate dehydrogenase inhibitor. Dimethylmalonic acid competitively inhibits succinate dehydrogenase, reduces SDH-mediated succinate accumulation, blocks a key step in oxidative phosphorylation, and decreases anti-inflammatory cytokine secretion and ROS production. Dimethylmalonic acid can be used in research on autism spectrum disorders .
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Referencia número: HY-W008484
No. CAS: 150114-71-9
Áreas de investigación:  

Infection

Aminopyralid is a synthetic auxin herbicide. Aminopyralid provides foliar and soil residual weed control, and also increases forage yield in bahiagrass pastures. When present as a soil residue, Aminopyralid causes phytotoxicity, reduced plant height, decreased flower number and fruit yield loss in rotated vegetable crops. Aminopyralid is registered for the control of annual and perennial broadleaf weeds in pastures, permanent grasslands and non-cropped areas .
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Referencia número: HY-W013058
No. CAS: 84852-53-9
Synonyms: DBDPE; 1,2-Bis(perbromophenyl)ethane
Áreas de investigación:  

Cancer

Decabromodiphenyl ethane (DBDPE) is a brominated flame retardant. Decabromodiphenyl ethane induces ROS-related cytotoxicity and apoptosis in human hepatoma cells, causes hepatocyte damage through oxidative stress, endoplasmic reticulum stress and decreased CYP3A expression, and accumulates and undergoes biotransformation in animal tissues. Decabromodiphenyl ethane can be used to study the environmental toxicology and biological effects of brominated flame retardants .
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Referencia número: HY-W750902
No. CAS: 2714484-46-3
Oxymatrine-d3 is the deuterium labeled Oxymatrine (HY-N0158). Oxymatrine, an alkaloid from Sophora flavescens Alt. with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. Oxymatrine inhibits bocavirus minute virus of canines (MVC) replication, reduces viral gene expression and decreases apoptosis induced by viral infection .
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Referencia número: HY-107855R
No. CAS: 674-26-0
Synonyms: (±)-Mevalonolactone (Standard); Mevalolactone (Standard)
DL-Mevalonolactone (Standard) is the analytical standard of DL-Mevalonolactone. This product is intended for research and analytical applications. DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone is orally active against HMGCR mutation and statin caused myopathy . DL-Mevalonolactone induces inflammation and oxidative stress response with decreased mitochondrial membrane potential (MMP) and induces mitochondrial swelling .
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Referencia número: HY-107855S2
No. CAS: 53771-22-5
Synonyms: (±)-Mevalonolactone-13C; Mevalolactone-13C
DL-Mevalonolactone- 13C ((±)-Mevalonolactone- 13C) is the 13C-labeled DL-Mevalonolactone (HY-107855). DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone is orally active against HMGCR mutation and statin caused myopathy. DL-Mevalonolactone induces inflammation and oxidative stress response with decreased mitochondrial membrane potential (MMP) and induces mitochondrial swelling.
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