Semorinemab
Based on 1 Customer Validation
Semorinemab (RG 6100) is an anti-Tau humanized IgG4 monoclonal antibody, targets the N-terminal portion of the Tau protein (amino acid residues 6-23). Semorinemab binds with human Tau with a Kd value of 3.8 nM. Semorinemab can be used for the research of Alzheimer's Disease.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.36%
- No. CAS: 2159141-27-0
- Peso molecular:145.1 kDa
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
Actividad biológica
Human IgG4 kappa
Human
Tau
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Tg mouse with the expression of human disease-causing tau mutant (TauP301L-Tg) [1]
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Dosage:3, 10 and 30 mg/kg
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Administration:Intraperitoneal injection; 3, 10 and 30 mg/kg, once weekly for 13 weeks
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Result:Reduced the accumulation of pathological tau, and dose-dependently decreased pTau212/214 and pTau202/205.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG4 kappa
ELISA, FACS, Functional assay
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Immobilized Human Tau Protein (His Tag) can bind Semorinemab. The EC50 for this effect is 4.02 ng/mL. -
Flow cytometric analysis of 1.5X106 SHSY5Y cells with Semorinemab (HY-P99399, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa, Isotype Control (HY-P99003, blue) was used as the isotype control.
Chemical Information
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No. CAS 2159141-27-0
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Appearance Liquid
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Peso molecular 145.1 kDa
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Color Colorless to light yellow
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SMILES
[Semorinemab]
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Synonyms
RG 6100; RO7105705; MTAU-9937A
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Envío
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
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Ficha de datos (259 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)