slCeMM1
Based on 1 Customer Validation
slCeMM1 is a selective SLC16A3 (MCT4) inhibitor. slCeMM1 inhibits lactate transport, induces intracellular lactate accumulation, reduces viability of SLC16A3-dependent cells, and inhibits growth of SLC16A3-dependent cells. slCeMM1 can be used for the research of rheumatoid arthritis and cancer.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.48%
- No. CAS: 949973-22-2
- Fòrmula: C20H17F3N6O
- Peso molecular:414.38
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
MCT4 |
In Vitro
slCeMM1 (serial dilutions; 72 h) potently and selectively inhibits viability of SLC16A3-dependent HAP1 SLC16A1-/- cells with an IC50 of 0.88 μM, while having no effect on HAP1 cells dependent on SLC16A1, SLC16A7, or SLC16A8[1].
slCeMM1 (serial dilutions; 6 h) induces intracellular lactate accumulation in SLC16A3-dependent HAP1 SLC16A1-/- cells with an IC50 of 91 nM, confirming inhibition of SLC16A3-mediated lactate export[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 949973-22-2
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Appearance Solid
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Peso molecular 414.38
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Fòrmula C20H17F3N6O
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SMILES
O=C(CCC1=C(C)N2N=C(C(F)(F)F)N=C2N=C1C)NC3=CN=C4C=CC=CC4=C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
slCeMM1 Related Classifications
HY-182416 Related Classifications
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