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Referencia número: HY-107625

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SNAP 94847

2 Cited Publications

Revisión del cliente

Based on 2 publication(s) in Google Scholar

SNAP 94847 is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCHR1) antagonist with (K_i= 2.2 nM, K_d=530 pM), it displays >80-fold and >500-fold selectivity over MCHα1A and MCHD2 receptors respectively. SNAP 94847 binds with high affinity to the mouse and rat MCHR1 with minimal cross-reactivity to other GPCR, ion channels, enzymes, and transporters.

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No. CAS: 487051-12-7
Fòrmula: C₂₉H₃₂F₂N₂O₂
Peso molecular:478.57

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

SNAP 94847 Chemical Structure

No. CAS: 487051-12-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vivo
Chemical Information
Publications (2)
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Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target

Ki: 2.2 nM (MCHR1); Kd: 530 pM (MCHR1)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	230 nM Compound: 16g, SNAP-94847	Antagonist activity at rat MCH1 receptor expressed in HEK293 cells by FLIPR calcium mobility assay Antagonist activity at rat MCH1 receptor expressed in HEK293 cells by FLIPR calcium mobility assay	[PMID: 17668922]

In Vivo

SNAP 94847 (oral gavage; 20 mg/kg; 14 days) shows an exaggerated locomotor response to acute quinpirole [treatment: F(2,19)=11.31, treatment × time: F(34,323) = 4.061], the effect of SNAP 94847 on quinpirole-evoked ambulations over the entire observation period is significant compared to the untreated animals^[2].
SNAP 94847 (oral administration; 20 mg/kg; 21 days) in drink water, produces a significant increase in ambulation relative to untreated animals [treatment: F(3,28) = 8.971; treatment × time: F(51,476)=11.50]. shows a marked increase in locomotion is apparent after 40 min in the SNAP 94847-treated group,this effect is significant over 180 min^[2].
SNAP 94847 (oral administration; 10 mg/kg), has a good bioavailability (59%), low plasma and blood clearances of 4.2 L/hr/kg and 3.3 L/hr/kg, respectively, and the half-life was shown to be 5.2 h in rats in a PK study^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Rat^[2]
Dosage:

20 mg/kg
Administration:

Oral administration; 20 mg/kg; 14 days
Result:

Exhibited a exaggerated locomotor response to acute quinpirole.

Animal Model:

Rat (PK study)^[3]
Dosage:

10 mg/kg
Administration:

oral gavage; 10 mg/kg
Result:

Exhibited good physicochemical properties in rats.

Chemical Information

No. CAS 487051-12-7
Peso molecular 478.57
Fòrmula C₂₉H₃₂F₂N₂O₂
SMILES

CC1=CC=C(NC(C(C)C)=O)C=C1C2CCN(CC3=CC=C(OC4=CC(F)=C(F)C=C4)C=C3)CC2
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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bioRxiv

2024 Mar 12.
Research Square Preprint

2021 Sep.

Pureza y Documentación

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Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. David DJ, et al. Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis. J Pharmacol Exp Ther. 2007 Apr;321(1):237-48. Epub 2007 Jan 19. [Content Brief]

[2]. Nair SG, et al. Effects of the MCH1 receptor antagonist SNAP 94847 on high-fat food-reinforced operant responding and reinstatement of food seeking in rats.Psychopharmacology (Berl). 2009 Jul;205(1):129-40. [Content Brief]

[3]. Chen CA, et al. Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 2: A hybrid strategy combining key fragments of HTS hits.J Med Chem. 2007 Aug 9;50(16):3883-90. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

SNAP 94847

2 Cited Publications

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (2)
Pureza y Documentación
Referencias

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SNAP 94847

Publications Citing Use of MedChemExpress (MCE) SNAP 94847

Actividad biológica

Chemical Information

Publications (2)

Pureza y Documentación

Referencias

Calculators

Help & FAQs

SNAP 94847 Related Classifications

HY-107625 Related Classifications