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Referencia número: HY-135655A

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Fobrepodacin

(Synonyms: SPR720; pVXc-486)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Fobrepodacin (SPR720) is an orally active and potent phosphate proagent of SPR719 (VXc-486; HY-12930). Fobrepodacin has potent bactericidal activities in vivo.

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No. CAS: 1384984-31-9
Fòrmula: C₂₁H₂₆FN₆O₆P
Peso molecular:508.44

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Fobrepodacin Chemical Structure

No. CAS: 1384984-31-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Actividad biológica

Descripciòn

Fobrepodacin (SPR720) is an orally active and potent phosphate proagent of SPR719 (VXc-486; HY-12930). Fobrepodacin has potent bactericidal activities in vivo^[1].

In Vivo

Fobrepodacin (oral gavage; 10, 30, 100 mg/kg; once per day; 5 times per week for 4 weeks) reduces the mycobacterial burden in a model of chronic tuberculosis infection in mice^[1].
Fobrepodacin (oral; 100 mg/kg; once per day; 5 days per week, for 8 weeks) improves the bactericidal activities of antimycobacterial drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Six-week old female BALB/c and C57BL/6 mice uninfected or M. tuberculosis-infected (Erdman)^[1]
Dosage:

10, 30, 100 mg/kg
Administration:

Oral gavage; once per day; 5 times per week for 4 weeks
Result:

Reduced the mycobacterial burden in a model of chronic tuberculosis infection in mice.

Chemical Information

No. CAS 1384984-31-9
Peso molecular 508.44
Fòrmula C₂₁H₂₆FN₆O₆P
SMILES

O=C(NC1=NC2=CC(C3=CN=C(C(OP(O)(O)=O)(C)C)N=C3)=C(F)C([C@@H]4OCCC4)=C2N1)NCC
Synonyms

SPR720; pVXc-486
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Antimicrob Agents Chemother

Multidrug tolerance conferred by loss-of-function mutations in anti-sigma factor RshA of Mycobacterium abscessus. [Abstract]

2024 Dec 5;68(12):e0105124. PMID: 39470195

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Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Locher CP, et al. A novel inhibitor of gyrase B is a potent drug candidate for treatment of tuberculosis and nontuberculosis mycobacterial infections.Antimicrob Agents Chemother. 2015 Mar;59(3):1455-65. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Fobrepodacin

1 Cited Publications

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Fobrepodacin

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