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Referencia número: HY-189759

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SQ-030

SQ-030 is a cPGES inhibitor with a human K_d of 0.315 μM. SQ-030 reduces lipid accumulation in hepatocytes. SQ-030 ameliorates hepatic dysfunction, hepatic steatosis, inflammation, and fibrosis in mice. SQ-030 alleviates hepatic dysfunction and lipid deposition in mice. SQ-030 can be used for research on metabolic dysfunction-associated steatotic liver disease (MASLD).

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No. CAS: 667880-05-9
Fòrmula: C₂₁H₂₁N₃O₅
Peso molecular:395.41

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

SQ-030 Chemical Structure

No. CAS: 667880-05-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- In Vitro
- In Vivo
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Descripciòn

Ver todos los productos específicos de isoformas HSP :

In Vitro

Lipid Metabolism

SQ-030 (PA + OA: 0.6 mM palmitate + 0.3 mM oleate; 24 h) reduces lipid accumulation in PA + OA-treated AML12 mouse hepatocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Innate ImmunityLipid Inflammatory MediatorsLipid Metabolism

Innate Immunity

Lipid Inflammatory Mediators

Lipid Metabolism

SQ-030 (1 mg/kg; i.p.; every other day; 4 weeks) ameliorates methionine-choline-deficient (MCD) diet-induced metabolic dysfunction-associated steatohepatitis (MASH), attenuating liver injury, steatosis, inflammation, and fibrosis without altering hepatic PGE₂-EP receptor signaling^[1].

Lipid Metabolism

SQ-030 alleviates high-fat diet (HFD)-induced hepatic dysfunction and lipid deposition^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J (male)^[1]
Dosage:

1 mg/kg
Administration:

i.p.; every other day; for 4 weeks
Result:

Alleviated liver dysfunction (serum AST and ALT), hepatic steatosis, inflammation, and fibrosis.
Relative NAS was lower in SQ-030-treated MCD mice than in controls.
Did not change hepatic PGE2 levels or mRNA expression of the four EP receptors (Ptger1-4).

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Chemical Information

No. CAS 667880-05-9
Peso molecular 395.41
Fòrmula C₂₁H₂₁N₃O₅
SMILES

CC1=C(C(OC)=O)C(C2=CC=C(OCC(NC3=CC=CC=C3)=O)C=C2)NC(N1)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Zhong D, et al. Cell-specific cPGES control of glucocorticoid receptor function drives MASLD progression. Cell reports. 2026 Sep 22;45(9):117901.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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SQ-030

Ver todos los productos específicos de isoformas HSP

Actividad biológica

Descripciòn

In Vitro

In Vivo

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

SQ-030 Related Classifications

HY-189759 Related Classifications

Bioz

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