SRI-37264
SRI-37264 is a HIV-1 Nef inhibitor with a Kd value of 162 nM. SRI-37264 binds directly to HIV-1 Nef, disrupts the Nef·MHC-I·AP-1 μ1 complex, and inhibits the Nef-dependent enhancement of HIV-1 infectivity. SRI-37264 restores MHC-I expression on the surface of HIV-infected primary cells. SRI-37264 inhibits HIV-1 replication in primary macrophages. SRI-37264 is applicable to research related to HIV-1 infection.
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- No. CAS: 2358714-71-1
- Fòrmula: C17H14ClN3O3S
- Peso molecular:375.83
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Actividad biológica
Descripciòn
In Vitro
SRI-37264 has excellent metabolic stability with a half-life > 2 h in mouse and human liver microsomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Parmacokinetics
| Species | Dose | Route | T1/2 |
|---|---|---|---|
| Mice[1] | 1 mg/kg | i.v. | 40 min |
Chemical Information
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No. CAS 2358714-71-1
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Peso molecular 375.83
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Fòrmula C17H14ClN3O3S
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SMILES
O=C1C2=CC=CN=C2SN1C3=CC=C(C(C(N4CCOCC4)=O)=C3)Cl
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SRI-37264 Related Classifications
HY-184379 Related Classifications
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