STL001
Based on 1 Customer Validation
STL001 is potent and selective FOXM1 inhibitor. STL001 induces the translocation of nuclear FOXM1 to the cytoplasm and promotes its autophagic degradation. STL001 sensitizes human cancers to a broad-spectrum of cancer therapies.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.81%
- No. CAS: 3047493-70-6
- Fòrmula: C27H23N7O4
- Peso molecular:509.52
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Bioactive Compound Library
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High-Throughput Bioactive Compound Library
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Actividad biológica
STL001 (1-10 μM; 24 h) causes a dose-dependent reduction of the cellular levels of FOXM1 protein[1].
STL001 (5 μM; 24 h) induces the translocation of nuclear FOXM1 to the cytoplasm and promotes its autophagic degradation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:OVCAR-8, ES-2, HCT-116, HCT-FET, FLO-1, TAM-R, HCC-1143, 22Rv1, LNCaP
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Concentration:1 μM, 5 μM, and 10 μM
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Incubation Time:24 h
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Result:Significantly reduced the cellular levels of FOXM1 protein.
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Cell Line:U2OS-C3-luc cells
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Concentration:5 μM
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Incubation Time:24 h
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Result:Resulted in reduced FOXM1 levels with increased expression of autophagy marker protein LC3.
Chemical Information
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No. CAS 3047493-70-6
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Appearance Solid
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Peso molecular 509.52
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Fòrmula C27H23N7O4
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Color White to off-white
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SMILES
O=C(C1=CC=CO1)OC2=CC(C3=NN(C=C3)C4=NC(NC5=CC=CC=C5)=NC(N6CCOCC6)=N4)=CC=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 5 mg/mL (9.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (277 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9626 mL | 9.8132 mL | 19.6263 mL | 49.0658 mL |
| 5 mM | 0.3925 mL | 1.9626 mL | 3.9253 mL | 9.8132 mL |
STL001 Related Classifications
HY-158420 Related Classifications
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