Thiotaurine
Based on 1 Customer Validation
Thiotaurine is the metabolite of Cystine. Thiotaurine is a sulfur donor, which may probably modulates the activity of GAPDH, followed by the pparticipation in neutrophil activation and leukocytes energy metabolism. Thiotaurine is a potential anti-inflammatory agent and immunomodulator.
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- Pureza : 99.27%
- No. CAS: 2937-54-4
- Fòrmula: C2H7NO2S2
- Peso molecular:141.21
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Almacenamiento:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
Chemical Information
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No. CAS 2937-54-4
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Appearance Solid
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Peso molecular 141.21
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Fòrmula C2H7NO2S2
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Color White to off-white
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SMILES
O=S(S)(CCN)=O
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvente y solubilidad
In Vitro:
DMSO : 100 mg/mL (708.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocolo
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Pureza y Documentación
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Ficha de datos (267 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.0817 mL | 35.4083 mL | 70.8165 mL | 177.0413 mL |
| 5 mM | 1.4163 mL | 7.0817 mL | 14.1633 mL | 35.4083 mL | |
| 10 mM | 0.7082 mL | 3.5408 mL | 7.0817 mL | 17.7041 mL | |
| 15 mM | 0.4721 mL | 2.3606 mL | 4.7211 mL | 11.8028 mL | |
| 20 mM | 0.3541 mL | 1.7704 mL | 3.5408 mL | 8.8521 mL | |
| 25 mM | 0.2833 mL | 1.4163 mL | 2.8327 mL | 7.0817 mL | |
| 30 mM | 0.2361 mL | 1.1803 mL | 2.3606 mL | 5.9014 mL | |
| 40 mM | 0.1770 mL | 0.8852 mL | 1.7704 mL | 4.4260 mL | |
| 50 mM | 0.1416 mL | 0.7082 mL | 1.4163 mL | 3.5408 mL | |
| 60 mM | 0.1180 mL | 0.5901 mL | 1.1803 mL | 2.9507 mL | |
| 80 mM | 0.0885 mL | 0.4426 mL | 0.8852 mL | 2.2130 mL | |
| 100 mM | 0.0708 mL | 0.3541 mL | 0.7082 mL | 1.7704 mL |
Thiotaurine Related Classifications
HY-N15156 Related Classifications
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