THP-NCS
THP-NCS is a bifunctional chelator bearing an isothiocyanate group, enabling radiolabeling. THP-NCS can conjugate antibody fragments for gallium isotope radiolabeling in ImmunoPET imaging. THP-NCS can conjugate biomolecules, including cyclic RGD peptides. THP-NCS can conjugate PEGylated liposomes or bone-targeting aminobisphosphonates via thiourea bonds for metal chelation pretargeting.
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- No. CAS: 1807847-98-8
- Fòrmula: C66H74N10O10S2
- Peso molecular:1231.48
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Ver todos los productos específicos de isoformas Radionuclide-Drug Conjugates (RDCs)
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
RDC Bifunctional Chelator |
In Vitro
THP-NCS is linked via a lysine side chain to the cyclic pentapeptide c (RGDfK). The "RGD" peptide motif targets the αvβ3 integrin receptor, which is expressed on the surface of many metastatic tumor cells, as well as on inflammatory tissue and the surface of blood vessels undergoing angiogenesis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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No. CAS 1807847-98-8
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Peso molecular 1231.48
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Fòrmula C66H74N10O10S2
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SMILES
O=C1C=C(C)N(C)C(CNC(CCC(CCC(NCC2=C(C(C=C(C)N2C)=O)OCC3=CC=CC=C3)=O)(CCC(NCC4=C(C(C=C(C)N4C)=O)OCC5=CC=CC=C5)=O)NC(CCNC(NC6=CC=C(C=C6)N=C=S)=S)=O)=O)=C1OCC7=CC=CC=C7
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
THP-NCS Related Classifications
HY-159183 Related Classifications
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