TP-024
Based on 2 publication(s) in Google Scholar
TP-024 (FTBMT), a chemical probe, is a selective GPR52 agonist with an EC50 of 75 nM. TP-024 has antipsychotic and procognitive properties.
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- Pureza: 99.41%
- No. CAS: 1358575-02-6
- Fòrmula: C19H16F4N4O
- Peso molecular:392.35
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Publications Citing Use of MedChemExpress (MCE) TP-024
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Actividad biológica
IC50: 75 nM (GPR52)[1]
TP-024 (FTBMT) (0.1-10 μM) increases intracellular cAMP levels in CHO cells expressing human, mouse, or rat GPR52, with pEC50s of 7.03, 6.85, and 6.87, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CHO cells (expressing GPR52 receptors) cAMP assay
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Concentration:0.1-10 μM
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Incubation Time:30 minutes
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Result:FTBMT activated cAMP signaling in vitro[1].
TP-024 (3 or 10 mg/kg, 48 hours) improves recognition and spatial working memory in rats[2].
TP-024 (3, 10, 30 mg/kg, 2 hours) stimulates neuronal activity in brain regions related to cognition[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Long-Evans rats (9 weeks old)[2]
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Dosage:10 mg/kg
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Administration:Oral, 1 hour before memory test
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Result:A 1-hour pretreatment with FTBMT (10 mg/kg, p.o.) significantly decreases the number of memory errors induced by MK-801[2].
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Animal Model:Male ICR mice (7 to 8 weeks old)[2]
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Dosage:3–30 mg/kg
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Administration:Oral, 60 minutes before s.c. administration of MK-801
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Result:FTBMT increases phospho-DARPP32 levels in the NAc slices[2].
Chemical Information
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No. CAS 1358575-02-6
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Appearance Solid
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Peso molecular 392.35
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Fòrmula C19H16F4N4O
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Color Brown to orange
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SMILES
O=C(N)C1=CC=C(N2C(C)=NC(CC3=CC(C(F)(F)F)=CC(F)=C3)=N2)C=C1C
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Synonyms
FTBMT
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Nat Commun
Human iPSC-based Modeling of Pulmonary Fibrosis Reveals p300/CBP Inhibition Suppresses Alveolar Transitional Cell State. [Abstract]2026 Feb 12;17(1):1214. PMID: 41680175 -
TP-024 purchased from MedChemExpress. Usage Cited in: Universität Hamburg. 2022 Oct.
FRET response after FTBMT stimulation in HEK293A cells transfected with an empty backbone vector (Control) was negligible. Maximal response of FRET sensor was induced by adding 10 µM FSK and 100 µM IBMX (TP-024).
Solvente y solubilidad
DMSO : 50 mg/mL (127.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Tokumaru K, et al. Design, synthesis, and pharmacological evaluation of 4-azolyl-benzamide derivatives as novel GPR52 agonists. Bioorg Med Chem. 2017 Jun 15;25(12):3098-3115. [Content Brief]
[2]. Nishiyama K, et al. FTBMT, a Novel and Selective GPR52 Agonist, Demonstrates Antipsychotic-Like and Procognitive Effects in Rodents, Revealing a Potential Therapeutic Agent for Schizophrenia. J Pharmacol Exp Ther. 2017 Nov;363(2):253-264. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5487 mL | 12.7437 mL | 25.4874 mL | 63.7186 mL |
| 5 mM | 0.5097 mL | 2.5487 mL | 5.0975 mL | 12.7437 mL | |
| 10 mM | 0.2549 mL | 1.2744 mL | 2.5487 mL | 6.3719 mL | |
| 15 mM | 0.1699 mL | 0.8496 mL | 1.6992 mL | 4.2479 mL | |
| 20 mM | 0.1274 mL | 0.6372 mL | 1.2744 mL | 3.1859 mL | |
| 25 mM | 0.1019 mL | 0.5097 mL | 1.0195 mL | 2.5487 mL | |
| 30 mM | 0.0850 mL | 0.4248 mL | 0.8496 mL | 2.1240 mL | |
| 40 mM | 0.0637 mL | 0.3186 mL | 0.6372 mL | 1.5930 mL | |
| 50 mM | 0.0510 mL | 0.2549 mL | 0.5097 mL | 1.2744 mL | |
| 60 mM | 0.0425 mL | 0.2124 mL | 0.4248 mL | 1.0620 mL | |
| 80 mM | 0.0319 mL | 0.1593 mL | 0.3186 mL | 0.7965 mL | |
| 100 mM | 0.0255 mL | 0.1274 mL | 0.2549 mL | 0.6372 mL |
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