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Referencia número: HY-181890

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TRG-192

TRG-192 is a potent and selective glutaminase (GLS) inhibitor with an IC₅₀ of 68 nM. TRG-192 inhibits intracellular glutamate levels. TRG-192 is applicable to related research on non-small cell lung cancer.

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No. CAS: 3080792-24-8
Fòrmula: C₂₄H₂₀F₆N₈O₂S₂
Peso molecular:630.59

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

TRG-192 Chemical Structure

No. CAS: 3080792-24-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocolo (1)
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

IC₅₀ & Target

IC₅₀: 68 nM (GLS)^[1]

In Vitro

TRG-192 potently inhibits glutaminase in cell-free in vitro biochemical assays, with an IC₅₀ of 68 nM^[1].
TRG-192 (0.01-1 μM; 72 h) potently inhibits the proliferation of glutamine-addicted NSCLC cell lines (A549, H460, H358), with IC₅₀ values of 0.068 μM, 0.038 μM and 0.035 μM respectively after 72 h of treatment^[1].
TRG-192 (0.3 μM; 24 h) significantly reduces intracellular glutamate levels in LDK378-resistant (LR) cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

No. CAS 3080792-24-8
Peso molecular 630.59
Fòrmula C₂₄H₂₀F₆N₈O₂S₂
SMILES

O=C(NCC1=NC=CC(C(F)(F)F)=C1)C2=NN=C(CCCCC3=NN=C(C(NCC4=NC=CC(C(F)(F)F)=C4)=O)S3)S2
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocolo

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Cyriac R, et al. Design, synthesis and biological evaluation of symmetric thiadiazole carboxamide derivative as glutaminase inhibitor. Bioorg Med Chem Lett. Published online February 21, 2026. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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