TRG-192
TRG-192 is a potent and selective glutaminase (GLS) inhibitor with an IC50 of 68 nM. TRG-192 inhibits intracellular glutamate levels. TRG-192 is applicable to related research on non-small cell lung cancer.
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- No. CAS: 3080792-24-8
- Fòrmula: C24H20F6N8O2S2
- Peso molecular:630.59
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
IC50: 68 nM (GLS)[1]
In Vitro
TRG-192 potently inhibits glutaminase in cell-free in vitro biochemical assays, with an IC50 of 68 nM[1].
TRG-192 (0.01-1 μM; 72 h) potently inhibits the proliferation of glutamine-addicted NSCLC cell lines (A549, H460, H358), with IC50 values of 0.068 μM, 0.038 μM and 0.035 μM respectively after 72 h of treatment[1].
TRG-192 (0.3 μM; 24 h) significantly reduces intracellular glutamate levels in LDK378-resistant (LR) cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 3080792-24-8
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Peso molecular 630.59
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Fòrmula C24H20F6N8O2S2
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SMILES
O=C(NCC1=NC=CC(C(F)(F)F)=C1)C2=NN=C(CCCCC3=NN=C(C(NCC4=NC=CC(C(F)(F)F)=C4)=O)S3)S2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TRG-192 Related Classifications
HY-181890 Related Classifications
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