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Tusamitamab

(Synonyms: SAR-408377; PF-08046050 Antibody; SAR445953 Antibody)
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Based on 1 Customer Validation

Tusamitamab is an IgG1 monoclonal antibody that targets CEACAM5. Tusamitamab can be used to synthesize ADC Tusamitamab ravtansine (SAR408701) (HY-P99542).

Para uso exclusivo en investigación. No vendemos a pacientes.

  • Pureza: 99.81%
  • No. CAS: 2349294-95-5
  • Peso molecular:144.76 kDa
  • Almacenamiento:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Tusamitamab
  • Experimental Validation Results for Tusamitamab
  • Experimental Validation Results for Tusamitamab
  • Experimental Validation Results for Tusamitamab
  • Tusamitamab Chemical Structure
  • Experimental Validation Results for Tusamitamab
  • Experimental Validation Results for Tusamitamab
  • Experimental Validation Results for Tusamitamab
  • Experimental Validation Results for Tusamitamab
  • Tusamitamab Chemical Structure
    Tusamitamab Chemical Structure
No. CAS: 2349294-95-5
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Encuentre su distribuidor local Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Loaded Tusamitamab on AHC2 biosensor, can bind CEACAM5 Protein, Human (HEK293, His, solution, HY-P75356) with an affinity constant of 6.031E-09 M as determined in BLI assay.

  • 1/16

    Immobilized CEACAM5 Protein, Human can bind Tusamitamab. The EC50 for this effect is 4.02 ng/mL.

  • 1/16

    Flow Cytometry analysis of MCF-7 cells with Tusamitamab (HY-P99054, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Tusamitamab Chemical Structure
    1/16
  • Tusamitamab
  • Loaded Tusamitamab on AHC2 biosensor, can bind CEACAM5 Protein, Human (HEK293, His, solution, HY-P75356) with an affinity constant of 6.031E-09 M as determined in BLI assay.
  • Immobilized CEACAM5 Protein, Human can bind Tusamitamab. The EC50 for this effect is 4.02 ng/mL.
  • Flow Cytometry analysis of MCF-7 cells with Tusamitamab (HY-P99054, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).