UHMCP1
Based on 1 Customer Validation
UHMCP1 is a chemical probe of U2AF homology motifs (UHM) with a Kd of 79 μM. UHMCP1 prevents the SF3b155/U2AF65 interaction, impacts RNA splicing and cell viability. UHMCP1 has potential anticancer properties.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.68%
- No. CAS: 2103079-87-2
- Fòrmula: C19H27N3
- Peso molecular:297.44
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
Kd: 79 µM (UHM domain)[1]
In Vitro
UHMCP1 (25-400 μM) reduces the binding of purified U2AF65 to SF3b155 by 75%, exhibiting a simple, non-cooperative binding mode with Kd around 30 μM for U2AF65[1].
UHMCP1 (0-200 μM; 24 h) exhibits a certain effect on cell viability of HEK293[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK293 cells
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Concentration:0-100 µM
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Incubation Time:24 h
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Result:Inhibited cell viability with an EC50 value of 140 µM.
Chemical Information
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No. CAS 2103079-87-2
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Appearance Solid
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Peso molecular 297.44
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Fòrmula C19H27N3
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Color Light yellow to brown
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SMILES
CC(N(C[C@]1([H])CC2)C[C@]2([H])[C@H]1N)CCC3=CNC4=CC=CC=C34
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 100 mg/mL (336.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3620 mL | 16.8101 mL | 33.6202 mL | 84.0506 mL |
| 5 mM | 0.6724 mL | 3.3620 mL | 6.7240 mL | 16.8101 mL | |
| 10 mM | 0.3362 mL | 1.6810 mL | 3.3620 mL | 8.4051 mL | |
| 15 mM | 0.2241 mL | 1.1207 mL | 2.2413 mL | 5.6034 mL | |
| 20 mM | 0.1681 mL | 0.8405 mL | 1.6810 mL | 4.2025 mL | |
| 25 mM | 0.1345 mL | 0.6724 mL | 1.3448 mL | 3.3620 mL | |
| 30 mM | 0.1121 mL | 0.5603 mL | 1.1207 mL | 2.8017 mL | |
| 40 mM | 0.0841 mL | 0.4203 mL | 0.8405 mL | 2.1013 mL | |
| 50 mM | 0.0672 mL | 0.3362 mL | 0.6724 mL | 1.6810 mL | |
| 60 mM | 0.0560 mL | 0.2802 mL | 0.5603 mL | 1.4008 mL | |
| 80 mM | 0.0420 mL | 0.2101 mL | 0.4203 mL | 1.0506 mL | |
| 100 mM | 0.0336 mL | 0.1681 mL | 0.3362 mL | 0.8405 mL |
UHMCP1 Related Classifications
HY-148384 Related Classifications
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