country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Referencia número: HY-134616

Copy Link Print Information

Ulinastatin

Name: Ulinastatin
Brand: MedChemExpress
SKU: HY-134616
Price: 50.00 USD
Availability: InStock
Rating: 5 (5 reviews)

(Synonyms: Uristatin)

5 Cited Publications

Revisión del cliente

Based on 5 publication(s) in Google Scholar

Ulinastatin (Uristatin) is a trypsin and serine protease inhibitor. Ulinastatin is the main protein binding inhibitor of various trypsin, chymotrypsin, and various pancreatic proteases. Ulinastatin shows neuroprotective, anti-inflammatory, anti-apoptotic, anti-oxidant effects.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 80449-31-6

Almacenamiento:

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Ulinastatin Chemical Structure

No. CAS: 80449-31-6

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
- In Vivo
- Ensayo clínico
Chemical Information
Publications (5)
Solvente y solubilidad
- In Vitro
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

In Vitro

Ulinastatin (500-5000 U; 24 hours) markedly attenuates TLR4 expression and NF-κB activation in LPS-stimulated BEAS-2B cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Human lung epithelial BEAS-2B cells
Concentration:

500 U, 2500 U, 5000 U
Incubation Time:

24 hours
Result:

Markedly attenuated TLR4 expression and NF-κB activation in LPS-stimulated BEAS-2B cells.

In Vivo

Ulinastatin (10000 U/kg; i.v.; twice) significantly protects animals from LPS-induced acute lung injury (ALI), decreasing the lung wet/dry weight ratio, ALI score, total cells, neutrophils, macrophages, myeloperoxidase activity, and malondialdehyde content, factors associated with lung histological damage^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male C57BL/6 mice (8-10 weeks old, 18-22 g)^[1]
Dosage:

10000 U/kg
Administration:

i.v.; twice (1 h before and 6 h after LPS treatment)
Result:

Significantly protected animals from LPS-induced ALI.

Ensayo clínico

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

No. CAS 80449-31-6
Appearance Solid
Color White to off-white
SMILES

[Ulinastatin]
Synonyms

Uristatin
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (5)

All Histological Imaging/StainingIFRT-PCRWBIHC

Sort by:

Journal Impact Factor

Phytomedicine

Qingjie Huagong decoction inhibits pancreatic acinar cell pyroptosis by regulating circHipk3/miR-193a-5p/NLRP3 pathway. [Abstract]

2024 Apr:126:155265. PMID: 38422649
Acta Pharmacol Sin

A sinomenine derivative protects life-threatening inflammatory injuries via covalently binding to a novel allosteric inhibition site of IRF3. [Abstract]

2026 Jan 16. PMID: 41545756
Eur J Pharmacol

Octreotide attenuates experimental severe acute pancreatitis through inhibiting pyroptosis and modulating intestinal homeostasis. [Abstract]

2025 May 5:994:177314. PMID: 39922420
J Ovarian Res

Ulinastatin protects against cisplatin-induced ovarian damage via Nrf2/Keap1 pathway. [Abstract]

2025 Sep 29;18(1):207. PMID: 41024007

Ulinastatin purchased from MedChemExpress. Usage Cited in: J Ovarian Res. 2025 Sep 29;18(1):207. [Abstract]

H&E staining results of rat ovaries treated with cisplatin on days 14 and 35 treated with Ulinastatin (15, 30 mg/kg, i.p.).

Ulinastatin purchased from MedChemExpress. Usage Cited in: J Ovarian Res. 2025 Sep 29;18(1):207. [Abstract]

TUNEL staining of ovarian tissues of rats treated with Ulinastatin (15, 30 mg/kg, i.p.).

Ulinastatin purchased from MedChemExpress. Usage Cited in: J Ovarian Res. 2025 Sep 29;18(1):207. [Abstract]

qPCR results of Keap1, Nrf2, TGFβ-1, FN, Cleaved-caspase3, BAX, and Bcl2 in cells of each group after treatment with Ulinastatin (15, 30 mg/kg, i.p.) on day 14 using Cisplatin.

Ulinastatin purchased from MedChemExpress. Usage Cited in: J Ovarian Res. 2025 Sep 29;18(1):207. [Abstract]

WB results of Keap1, Nrf2, TGFβ-1, FN, Cleaved-caspase3, BAX, and Bcl2 in cells of each group after treatment with Ulinastatin (15, 30 mg/kg, i.p.) on days 14 and 35 using Cisplatin.

Ulinastatin purchased from MedChemExpress. Usage Cited in: J Ovarian Res. 2025 Sep 29;18(1):207. [Abstract]

Immunohistochemical results of Keap1, Nrf2, TGFβ-1, and FN in cells of each group after treatment with Ulinastatin (15, 30 mg/kg, i.p.) on day 14 of Cisplatin use.
Vita

2026 Apr 7.

Solvente y solubilidad

In Vitro:

H₂O : 10 mg/mL (Need ultrasonic)

DMSO : 1 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (270 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Shangping Fang, et al. Research progress of ulinastatin in the treatment of liver diseases. Int J Clin Exp Pathol. 2020 Nov 1;13(11):2720-2726. [Content Brief]

[2]. Cao C, et al. Ulinastatin Protects Against LPS-Induced Acute Lung Injury By Attenuating TLR4/NF-κB Pathway Activation and Reducing Inflammatory Mediators. Shock. 2018 Nov;50(5):595-605. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Ulinastatin

5 Cited Publications

100 mg Obtener un presupuesto

Subscribe to the

MedChemExpress

Newsletter

MOQ

Minimum order quantity

100 mg

Obtener un presupuesto En stock

Other size

Obtener un presupuesto

Amount: USD 0.00

Actividad biológica
- Descripciòn
- In Vitro
- In Vivo
- Ensayo clínico
Chemical Information
Publications (5)
Solvente y solubilidad
- In Vitro
Pureza y Documentación
Referencias

1/16
1/16

Ulinastatin purchased from MedChemExpress. Usage Cited in: J Ovarian Res. 2025 Sep 29;18(1):207. [Abstract]

Customer Validation
H&E staining results of rat ovaries treated with cisplatin on days 14 and 35 treated with Ulinastatin (15, 30 mg/kg, i.p.).
1/16

Ulinastatin purchased from MedChemExpress. Usage Cited in: J Ovarian Res. 2025 Sep 29;18(1):207. [Abstract]

Customer Validation
TUNEL staining of ovarian tissues of rats treated with Ulinastatin (15, 30 mg/kg, i.p.).
1/16

Ulinastatin purchased from MedChemExpress. Usage Cited in: J Ovarian Res. 2025 Sep 29;18(1):207. [Abstract]

Customer Validation
qPCR results of Keap1, Nrf2, TGFβ-1, FN, Cleaved-caspase3, BAX, and Bcl2 in cells of each group after treatment with Ulinastatin (15, 30 mg/kg, i.p.) on day 14 using Cisplatin.
1/16

Ulinastatin purchased from MedChemExpress. Usage Cited in: J Ovarian Res. 2025 Sep 29;18(1):207. [Abstract]

Customer Validation
WB results of Keap1, Nrf2, TGFβ-1, FN, Cleaved-caspase3, BAX, and Bcl2 in cells of each group after treatment with Ulinastatin (15, 30 mg/kg, i.p.) on days 14 and 35 using Cisplatin.
1/16

Ulinastatin purchased from MedChemExpress. Usage Cited in: J Ovarian Res. 2025 Sep 29;18(1):207. [Abstract]

Customer Validation
Immunohistochemical results of Keap1, Nrf2, TGFβ-1, and FN in cells of each group after treatment with Ulinastatin (15, 30 mg/kg, i.p.) on day 14 of Cisplatin use.

Nombre del producto:
Referencia número:
Cantidad:
MCE Japan Authorized Agent:

Nombre del producto:
No. CAS:
Species:
Pureza:
Cantidad:

Ulinastatin

Publications Citing Use of MedChemExpress (MCE) Ulinastatin