Valopicitabine
Valopicitabine (NM283) is a nucleoside analog and the orally bioavailable proagent of the potent anti-HCV agent 2'-C-methylcytidine (NM107). NM107competitively inhibits NS5B polymerase, causing chain termination.
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- No. CAS: 640281-90-9
- Fòrmula: C15H24N4O6
- Peso molecular:356.37
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
HCV[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | CC50 |
>100 μM
Compound: valopicitabaine
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Cytotoxicity against Huh7 cells after 24 hrs by MTS assay
Cytotoxicity against Huh7 cells after 24 hrs by MTS assay
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[PMID: 17521911] |
| Huh-7 | CC50 |
>100 μM
Compound: 1
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Cytotoxicity against human HuH7 cells assessed as cell viability
Cytotoxicity against human HuH7 cells assessed as cell viability
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[PMID: 19493593] |
| Huh-7 | EC50 |
1.5 μM
Compound: valopicitabaine
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Antiviral activity against HCV genotype 1b in Huh7 cells assessed as inhibition of viral RNA replication after 72 hrs by ribonuclease protection assay
Antiviral activity against HCV genotype 1b in Huh7 cells assessed as inhibition of viral RNA replication after 72 hrs by ribonuclease protection assay
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[PMID: 17521911] |
| Huh-7 | EC50 |
7.45 μM
Compound: valopicitabaine
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Antiviral activity against HCV genotype 1b in Huh7 cells assessed as inhibition of viral RNA replication after 24 hrs by ribonuclease protection assay
Antiviral activity against HCV genotype 1b in Huh7 cells assessed as inhibition of viral RNA replication after 24 hrs by ribonuclease protection assay
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[PMID: 17521911] |
| Huh-7 | EC50 |
7.6 μM
Compound: 1
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Antiviral activity against HCV infected in human HuH7 cells by cell-based subgenomic replicon assay
Antiviral activity against HCV infected in human HuH7 cells by cell-based subgenomic replicon assay
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[PMID: 19493593] |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 640281-90-9
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Peso molecular 356.37
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Fòrmula C15H24N4O6
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SMILES
C[C@@]1([C@@](N2C(N=C(C=C2)N)=O)([H])O[C@@H]([C@H]1OC([C@@H](N)C(C)C)=O)CO)O
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Synonyms
NM283
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Pierra C, et al. Nm 283, an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine. Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):767-70. [Content Brief]
[2]. Pierra C, et al. Synthesis and pharmacokinetics of valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine. J Med Chem. 2006 Nov 2;49(22):6614-20. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Valopicitabine Related Classifications
HY-108060 Related Classifications
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