Vaxfectin
Based on 1 Customer Validation
Vaxfectin is a second-generation cationic lipid-based suspension that adjuvants effectively both pDNA and protein-based vaccines. Vaxfectin can boost the immune response against a range of pDNA-expressed pathogenic antigens in vivo. Vaxfectin can increase IgG titers and give rise to an IL-6 dependent enhancement of the humoral immune response without altering the Th1 type immune response. Vaxfectin can be studied for vaccine formulation.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.94%
- No. CAS: 370108-99-9
- Fòrmula: C81H163BrN3O10P
- Peso molecular:1450.05
-
Almacenamiento:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
HY-112251
D-Lin-MC3-DMAsiRNA Delivery Vehicle -
HY-125853
Phosphatidylcholines,soyaPhosphatidylcholine -
HY-145405
C12-200Cationic Lipidoid -
HY-141571
DOPG sodiumBiochemical Assay Reagent -
HY-112757
DLinDMAIonizable Cationic Lipid -
HY-W440821
m-PEG-DMG (MW 2000)PEG Lipid -
HY-156448
80-O14BLipid-like Compound -
HY-112251GL
D-Lin-MC3-DMA (GMP Like)Liposome
Actividad biológica
Descripciòn
In Vitro
In Vivo
Vaxfectin (i.m., single dose) formulated VR4700 (25 μg per muscle) results in stronger CTL responses in mice[2].
Vaxfectin (i.m., single dose) formulated VR4700 (5 μg) increases the number of antigen-specific plasma cells in bone marrow[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
No. CAS 370108-99-9
-
Appearance Oil
-
Peso molecular 1450.05
-
Fòrmula C81H163BrN3O10P
-
Color Light yellow to yellow
-
SMILES
NCCOP(OC[C@H](OC(CC(C)CCCC(C)CCCC(C)CCCC(C)C)=O)COC(CC(C)CCCC(C)CCCC(C)CCCC(C)C)=O)(O)=O.CCCC/C=C\CCCCCCCCOCC(C[N+](C)(C)CCCN)OCCCCCCCC/C=C\CCCC.[Br-]
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvente y solubilidad
In Vitro:
Ethanol : 100 mg/mL (68.96 mM; Need ultrasonic)
DMSO : 100 mg/mL (68.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureza y Documentación
-
Ficha de datos (276 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
[1]. Sullivan SM, et, al. Vaxfectin: a versatile adjuvant for plasmid DNA- and protein-based vaccines. Expert Opin Drug Deliv. 2010 Dec;7(12):1433-46. [Content Brief]
[2]. Hartikka, J., et al., (2001). Vaxfectin enhances the humoral immune response to plasmid DNA-encoded antigens. Vaccine, 19(15-16), 1911–1923. [Content Brief]
[3]. Reyes, L., et al., (2001). Vaxfectin enhances antigen specific antibody titers and maintains Th1 type immune responses to plasmid DNA immunization. Vaccine, 19(27), 3778–3786. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / DMSO | 1 mM | 0.6896 mL | 3.4482 mL | 6.8963 mL | 17.2408 mL |
| 5 mM | 0.1379 mL | 0.6896 mL | 1.3793 mL | 3.4482 mL | |
| 10 mM | 0.0690 mL | 0.3448 mL | 0.6896 mL | 1.7241 mL | |
| 15 mM | 0.0460 mL | 0.2299 mL | 0.4598 mL | 1.1494 mL | |
| 20 mM | 0.0345 mL | 0.1724 mL | 0.3448 mL | 0.8620 mL | |
| 25 mM | 0.0276 mL | 0.1379 mL | 0.2759 mL | 0.6896 mL | |
| 30 mM | 0.0230 mL | 0.1149 mL | 0.2299 mL | 0.5747 mL | |
| 40 mM | 0.0172 mL | 0.0862 mL | 0.1724 mL | 0.4310 mL | |
| 50 mM | 0.0138 mL | 0.0690 mL | 0.1379 mL | 0.3448 mL | |
| 60 mM | 0.0115 mL | 0.0575 mL | 0.1149 mL | 0.2873 mL |
Vaxfectin Related Classifications
HY-142998 Related Classifications
Powered by Bioz