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Referencia número: HY-174430

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WWQ-131

WWQ-131 is a potent selective JAK2 inhibitor with an IC₅₀ of 2.56 nM. WWQ-131 shows >252-fold selectivity over JAK1, JAK3, and TYK2. WWQ-131 exhibits antiproliferative activity against cancer cells. WWQ-131 is the ligand for target protein for PROTAC JAK2 degrader-1 (HY-174428). WWQ-131 can be used for the research of myeloproliferative neoplasms (MPNs).

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No. CAS: 1558007-80-9
Fòrmula: C₂₁H₂₃ClFN₅O
Peso molecular:415.89

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

WWQ-131 Chemical Structure

No. CAS: 1558007-80-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
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Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

JAK2

2.56 nM (IC₅₀)

JAK1

647.35 nM (IC₅₀)

JAK3

528.61 nM (IC₅₀)

Tyk2

1298.13 nM (IC₅₀)

Ver todos los productos específicos de isoformas JAK :

Cellular Effect

Cell Line	Type	Value	Description	References
NIH3T3	IC₅₀	387 nM Compound: 1a	Inhibition of human EML4-fused ALK L1196M mutant expressed in mouse NIH-3T3 cells assessed as phospho-ALK level after 1 hr by sandwich ELISA Inhibition of human EML4-fused ALK L1196M mutant expressed in mouse NIH-3T3 cells assessed as phospho-ALK level after 1 hr by sandwich ELISA	[PMID: 24432909]

In Vitro

WWQ-131 inhibits the proliferation of SET-2 and HEL cells with IC₅₀ values of 1.15 and 2.36 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 1558007-80-9
Peso molecular 415.89
Fòrmula C₂₁H₂₃ClFN₅O
SMILES

FC1=CC([C@H](OC2=C(N=CC(C3=CN(N=C3)C4CCNCC4)=C2)N)C)=C(C=C1)Cl
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Wang C, et al. Discovery of a Proteolysis-Targeting Chimera Degrader of JAK2 as a Potential Therapeutic Agent for JAK2-Mediated Myeloproliferative Neoplasms. J Med Chem. 2025;68(11):12085-12099. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Actividad biológica
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- IC₅₀ & Target
- In Vitro
Chemical Information
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WWQ-131

Ver todos los productos específicos de isoformas JAK

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Referencias

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WWQ-131 Related Classifications

HY-174430 Related Classifications