YTH-IN-2
YTH-IN-2 is a YTH domain inhibitor of YTHDC2 with an IC50 of 16.84 μM. YTH-IN-2 can serve as a lead compound for discovering efficient, selective, and cell-active small-molecule inhibitors of YTHDC2.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 86886-76-2
- Fòrmula: C14H12ClNO2
- Peso molecular:261.70
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
IC50 & Target
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YTHDC2 16.84 μM (IC50) |
In Vitro
YTH-IN-2 (H3) (30 min compound-protein incubation; 2 h post-probe addition incubation) inhibits recombinant human GST-tagged YTHDC2 YTH-domain protein binding to FAM-labeled m6A-mRNA with an IC50 of 16.84 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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No. CAS 86886-76-2
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Peso molecular 261.70
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Fòrmula C14H12ClNO2
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SMILES
O=C(CC1=CC=CC=C1)NC2=CC(Cl)=CC=C2O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
YTH-IN-2 Related Classifications
HY-181117 Related Classifications
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