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Referencia número: HY-P99509

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Zelminemab

(Synonyms: AMG-301)

Revisión del cliente

Based on 1 Customer Validation

Zelminemab (AMG-301) is a humanized monoclonal antibody that inhibits PACAP type I (PAC1) receptor.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza: 98.79%
No. CAS: 2225850-33-7
Peso molecular:145.22 kDa

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Zelminemab Chemical Structure

No. CAS: 2225850-33-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- In Vivo
- Ensayo clínico
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Aplicación
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Zelminemab (AMG-301) is a humanized monoclonal antibody that inhibits PACAP type I (PAC1) receptor^[1].

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

In Vivo

Zelminemab (10 mg/kg; i.v.; once) reduces nociceptive neu-ronal activity in the TCC^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley rats, electricalstimulation was performed on the intact dura mater abovethe middle meningeal artery^[2].
Dosage:

10 mg/kg
Administration:

i.v.; once
Result:

Induced an inhibition of stimulus-evoked nociceptive activity in the trigeminocervical com-plex (TCC).

Ensayo clínico

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

51237 [NCBI]

Accession

Q8WU39

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Human IgG1 kappa

Aplicación

ELISA, FACS, Functional assay

Chemical Information

No. CAS 2225850-33-7
Appearance Liquid
Peso molecular 145.22 kDa
Color Colorless to light yellow
SMILES

[Zelminemab]
Synonyms

AMG-301
Envío

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (256 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Referencias

[1]. Eloisa Rubio-Beltrán, et al. PACAP38 and PAC1 receptor blockade: a new target for headache? J Headache Pain. 2018 Aug 7;19(1):64. [Content Brief]

[2]. Hoffmann J, et al. PAC-1 receptor antibody modulates nociceptive trigeminal activity in rat. Cephalalgia. 2016;36(1S):141–141.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Actividad biológica
- Descripciòn
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- In Vivo
- Ensayo clínico
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Aplicación
Chemical Information
Pureza y Documentación
Referencias

Nombre del producto:
Referencia número:
Cantidad:
MCE Japan Authorized Agent:

Nombre del producto:
No. CAS:
Species:
Pureza:
Cantidad:

Zelminemab

SQ22536

2',5'-Dideoxyadenosine

NKH477

ST034307

LRE1

Peturadol

NKY80

CB-7921220

SQ22536 (Standard)

9-Cyclopentyladenine monomethanesulfonate

2',5'-Dideoxyadenosine (Standard)

NKY80 (Standard)

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Zelminemab

Cell-ATP Viability Detection Kit

HOLO Human Interleukin-2 (IL-2) Detection Kit

Protein A Agarose

Bradford Protein Assay Kit

Cytotoxicity LDH Assay Kit

PBS Buffer (1×)

DPBS Buffer (1×)

SQ22536

2',5'-Dideoxyadenosine

NKH477

ST034307

LRE1

Peturadol

NKY80

CB-7921220

SQ22536 (Standard)

9-Cyclopentyladenine monomethanesulfonate

2',5'-Dideoxyadenosine (Standard)

NKY80 (Standard)

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Zelminemab Related Classifications

HY-P99509 Related Classifications