Zoxamide
Based on 1 Customer Validation
Zoxamide (RH-7281) is an oomycete Fungicide and covalent β-tubulin inhibitor. RH-7281 inhibits the assembly of tubulin into microtubules in vitro. Zoxamide binds covalently to β-tubulin, disrupting microtubule assembly and the cytoskeleton. Zoxamide blocks nuclear division in germinated hyphae of Phytophthora capsici and inhibits hyphal growth of Phytophthora capsici.
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- Pureza : 99.05%
- No. CAS: 156052-68-5
- Fòrmula: C14H16Cl3NO2
- Peso molecular:336.64
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
Descripciòn
In Vitro
Studies show that all field-collected isolates of Phytophthora cactorum are sensitive to zoxamide (0.02-1.0 mg/L; 6 days), with a mean EC50 value of 0.14 mg/L for inhibiting radial mycelial growth[1].
Zoxamide (0-1 ppm) rapidly and potently inhibits nuclear division in Phytophthora capsici seedlings[2].
Zoxamide (0.05 ppm; 30 min) completely disrupts the microtubule cytoskeleton in germ tubes of *Phytophthora capsici*, eliminating detectable microtubule filaments[2].
Zoxamide (5-30 μM; 1-8 h) inhibits in vitro microtubule assembly of tubulin isolated from bovine brain in a dose-dependent manner, and its inhibitory potency increases with prolonged pre-incubation time[2].
Zoxamide (16 h) potently inhibits the mycelial growth of *Phytophthora capsici* in microtiter plate assays, with an EC50 of 0.0031 ppm[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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No. CAS 156052-68-5
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Appearance Solid
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Peso molecular 336.64
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Fòrmula C14H16Cl3NO2
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Color White to off-white
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SMILES
O=C(NC(C)(CC)C(CCl)=O)C1=CC(Cl)=C(C)C(Cl)=C1
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Synonyms
RH-7281
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Protocolo
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Filamentous Fungal Mold Culture and Sporulation
Filamentous fungal mold culture and sporulation assays grow hyphae under defined nutritional and environmental conditions until asexual spores, commonly conidia, are produced; the main readouts are colony growth, sporulation onset, conidial yield, conidial morphology, viability, and, when relevant, downstream infectivity or stress phenotype.
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Phalloidin F-actin cytoskeleton staining
Phalloidin F-actin staining detects polymerized filamentous actin in fixed and permeabilized specimens by using fluorescent phalloidin or phalloidin-derived phallotoxins that bind actin filaments and generate a fluorescence microscopy readout corresponding to F-actin organization, including stress fibers, cortical actin, filament bundles, and tissue-specific actin networks. Phalloidin stabilizes F-actin by reducing actin subunit dissociation from filament ends, and fluorescent phallotoxins were established as tools for visualizing actin-containing structures in eukaryotic cells.
Pureza y Documentación
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Ficha de datos (267 KB)
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SDS (537 KB)
- English - EN (537 KB)
- Français - FR (537 KB)
- Deutsch - DE (537 KB)
- Norwegian - NO (537 KB)
- Español - ES (537 KB)
- Swedish - SV (537 KB)
- Italian - IT (537 KB)
- Korean - KR (537 KB)
- Portuguese - PT (537 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Zoxamide Related Classifications
HY-120921 Related Classifications
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