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Referencia número: HY-139815

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ZYJ-34c

ZYJ-34c is an orally active and potent histone deacetylase inhibitor (HDACi) with IC₅₀s of 0.056 μM and 0.146 μM for HDAC6 and HDAC8, respectively. ZYJ-34c causes G1 phase arrest in low concentration. ZYJ-34c has antiproliferative activities. ZYJ-34c exhibits antitumor potency in MDA-MB-231 and HCT116 xenograft models and possesses antimetastatic potential in a mouse hepatoma-22 (H22) pulmonary metastasis model.

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No. CAS: 1314556-93-8
Fòrmula: C₃₁H₄₂N₄O₇
Peso molecular:582.69

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

ZYJ-34c Chemical Structure

No. CAS: 1314556-93-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
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- IC₅₀ & Target
- Cellular Effect
Chemical Information
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Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

HDAC6

0.056 μM (IC₅₀)

HDAC8

0.146 μM (IC₅₀)

Ver todos los productos específicos de isoformas HDAC :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.77 μM Compound: 4, ZYJ-34c	Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 21714538]
HeLa	IC₅₀	0.052 μM Compound: 4, ZYJ-34c	Inhibition of HDAC in human HeLa cell nuclear extracts using Boc-Lys (acetyl)-AMC as substrate after 30 mins by fluorescence assay Inhibition of HDAC in human HeLa cell nuclear extracts using Boc-Lys (acetyl)-AMC as substrate after 30 mins by fluorescence assay	[PMID: 21714538]
HeLa	IC₅₀	56.1 μM Compound: 4, ZYJ-34c	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 21714538]
HL-60	IC₅₀	65.8 μM Compound: 4, ZYJ-34c	Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay	[PMID: 21714538]
K562	IC₅₀	3.47 μM Compound: 4, ZYJ-34c	Antiproliferative activity against human K562 cells after 48 hrs by MTT assay Antiproliferative activity against human K562 cells after 48 hrs by MTT assay	[PMID: 21714538]
MCF7	IC₅₀	3.2 μM Compound: 4, ZYJ-34c	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 21714538]
MDA-MB-231	IC₅₀	0.58 μM Compound: 4, ZYJ-34c	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 21714538]
MDA-MB-231	IC₅₀	2.56 μM Compound: 1	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 28757101]
NB-4	IC₅₀	2.69 μM Compound: 4, ZYJ-34c	Antiproliferative activity against human NB4 cells after 48 hrs by MTT assay Antiproliferative activity against human NB4 cells after 48 hrs by MTT assay	[PMID: 21714538]
PC-3	IC₅₀	0.83 μM Compound: 4, ZYJ-34c	Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay	[PMID: 21714538]
U-266	IC₅₀	0.69 μM Compound: 1	Antiproliferative activity against human U266 cells after 48 hrs by MTT assay Antiproliferative activity against human U266 cells after 48 hrs by MTT assay	[PMID: 28757101]
U-937	IC₅₀	0.56 μM Compound: 1	Antiproliferative activity against human U937 cells after 48 hrs by MTT assay Antiproliferative activity against human U937 cells after 48 hrs by MTT assay	[PMID: 28757101]

Chemical Information

No. CAS 1314556-93-8
Peso molecular 582.69
Fòrmula C₃₁H₄₂N₄O₇
SMILES

CC(C)(C)CC(N[C@@H]([C@@H](C)CC)C(N1[C@@H](CC2=CC=C(OCC(NO)=O)C=C2C1)C(NC3=CC=C(C=C3)OC)=O)=O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Yingjie Zhang, et al. Discovery of a tetrahydroisoquinoline-based hydroxamic acid derivative (ZYJ-34c) as histone deacetylase inhibitor with potent oral antitumor activities. J Med Chem. 2011 Aug 11;54(15):5532-9. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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ZYJ-34c

Ver todos los productos específicos de isoformas HDAC

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

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ZYJ-34c Related Classifications

HY-139815 Related Classifications