CCT2 - chaperonin containing TCP1 subunit 2 Gene

Also Known as CCTB; 99D8.1; PRO1633; CCT-beta; HEL-S-100n; TCP-1-beta

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10576

About CCT2

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:69,585,459-69,601,570 (from NCBI)

This gene has 14 transcripts (splice variants), 214 orthologues, 13 paralogues and is associated with 1 phenotype. Broad expression in testis (RPKM 107.5), bone marrow (RPKM 41.1) and 24 other tissues.

Summary

The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

CCT2 Products (2)

mRNA Protein Name
NM_001198842.2 NP_001185771.1 T-complex protein 1 subunit beta isoform 2
NM_006431.3 NP_006422.1 T-complex protein 1 subunit beta isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14532270 GOA
enables protein folding chaperone IDA
IDA: Inferred from direct assay
25467444 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
21753002 GOA
Biological Process GO Annotation Evidence References Source
involved in chaperone mediated protein folding independent of cofactor IMP
IMP: Inferred from mutant phenotype
25467444 GOA
acts upstream of or within chaperone-mediated protein complex assembly IMP
IMP: Inferred from mutant phenotype
20080638 GOA
involved in chaperone-mediated protein folding IDA
IDA: Inferred from direct assay
22133715 GOA
involved in positive regulation of telomerase RNA localization to Cajal body IMP
IMP: Inferred from mutant phenotype
25467444 GOA
acts upstream of positive regulation of telomere maintenance via telomerase IMP
IMP: Inferred from mutant phenotype
25467444 GOA
involved in protein folding IDA
IDA: Inferred from direct assay
30955883 GOA
involved in protein stabilization IMP
IMP: Inferred from mutant phenotype
25467444 GOA
acts upstream of positive effect scaRNA localization to Cajal body IMP
IMP: Inferred from mutant phenotype
25467444 GOA
Cellular Component GO Annotation Evidence References Source
part of chaperonin-containing T-complex IDA
IDA: Inferred from direct assay
23011926 GOA
part of chaperonin-containing T-complex IPI
IPI: Inferred from physical interaction
22133715 GOA
located in microtubule IDA
IDA: Inferred from direct assay
21525035 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCT2 Protein Structure

Cpn60_TCP1

Cpn60_TCP1: TCP-1/cpn60 chaperonin family (36 - 524)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 535 a.a.
Protein Preferred Names Protein Names

T-complex protein 1 subunit beta

  • T-complex protein 1, beta subunit

CCT2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CCT2 P78371 NPHP1 Homo sapiens C9J082
Validated Y2H
32814053
Intra
CCT2 P78371 NPHP1 Homo sapiens C9J082
Y2H Array
32814053
Intra
CCT2 P78371 NPHP1 Homo sapiens C9J082
Y2H Pooling
32814053
Intra
CCT2 P78371 TGOLN2 Homo sapiens O43493-5
Y2H Pooling
32814053
Intra
CCT2 P78371 TGOLN2 Homo sapiens O43493-5
Validated Y2H
32814053
Intra
CCT2 P78371 TGOLN2 Homo sapiens O43493-5
Y2H Array
32814053
Intra
CCT2 P78371 PRMT5 Homo sapiens O14744
Y2H Pooling
32814053
Intra
CCT2 P78371 PRMT5 Homo sapiens O14744
Validated Y2H
32814053
Intra
CCT2 P78371 PRMT5 Homo sapiens O14744
Y2H Array
32814053
Intra
CCT2 P78371 CCT5 Homo sapiens P48643
Anti Tag CoIP
35271311
Intra
CCT2 P78371 CCT5 Homo sapiens P48643
Anti Tag CoIP
33961781
Intra
CCT2 P78371 TCP1 Homo sapiens P17987
Anti Tag CoIP
33961781
Intra
CCT2 P78371 TCP1 Homo sapiens P17987
Anti Tag CoIP
35271311
Intra
CCT2 P78371 CCT4 Homo sapiens P50991
Y2H Prey Pooling
32296183
Intra
CCT2 P78371 CCT4 Homo sapiens P50991
Crosslink
30021884
Intra
CCT2 P78371 CCT4 Homo sapiens P50991
Anti Tag CoIP
35271311
Intra
CCT2 P78371 CCT4 Homo sapiens P50991
Y2H Array
32296183
Intra
CCT2 P78371 CCT4 Homo sapiens P50991
Anti Tag CoIP
33961781
Intra
CCT2 P78371 CCT7 Homo sapiens Q99832
Anti Tag CoIP
33961781
Intra
CCT2 P78371 CCT7 Homo sapiens Q99832
Crosslink
30021884
Intra
CCT2 P78371 CCT7 Homo sapiens Q99832
Anti Tag CoIP
35271311
Intra
CCT2 P78371 ZNRD2 Homo sapiens O60232
Y2H Prey Pooling
25416956
Intra
CCT2 P78371 ZNRD2 Homo sapiens O60232
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CCT2 Proteins

Cat. No. Product Name Accession Purity
HY-P72120 CCT2 Protein, Human (His-SUMO) P78371-1 (A2-C535) ≥ 90%, as determined by reducing SDS-PAGE.

CCT2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82575 CCT2 Antibody (YA2320) WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat
HY-P85385 CCT2 Antibody (YA5077) WB, IHC-P, IHC-F, ICC/IF, IF-Tissue, IP, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Bardet-Biedl Syndrome

  • Bbs

  • Biedl-Bardet Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02179 CCT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18028 Cct2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24501 Cct2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CCT2 VGNC VGNC:60576
Canis familiaris CCT2 VGNC VGNC:38922
Rattus norvegicus CCT2 RGD RGD:1359143
Macaca mulatta CCT2 VGNC VGNC:70745
Bos taurus CCT2 VGNC VGNC:26995
Mus musculus CCT2 MGD MGI:107186
Others CCT2 NCBI