Nod1 - nucleotide-binding oligomerization domain containing 1 Gene

Also Known as Card4; Nlrc1; C230079P11; F830007N14Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 107607

About Nod1

Chromosome 6: 54,900,934-54,949,597 reverse strand.GRCm39:CM000999.3

This gene has 6 transcripts (splice variants), 201 orthologues, 22 paralogues and is associated with 6 phenotypes. Broad expression in lung adult (RPKM 28.6), spleen adult (RPKM 22.7) and 19 other tissues.

Summary

Predicted to enable CARD domain binding activity; pattern recognition receptor activity; and protein homodimerization activity. Involved in positive regulation of dendritic cell antigen processing and presentation. Acts upstream of or within several processes, including positive regulation of cytokine production; positive regulation of intracellular signal transduction; and positive regulation of xenophagy. Located in phagocytic vesicle. Is expressed in several structures, including alimentary system; brain; olfactory epithelium; urinary system; and vibrissa. Human ortholog(s) of this gene implicated in asthma. Orthologous to human NOD1 (nucleotide binding oligomerization domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Nod1 Products (4)

mRNA Protein Name
NM_172729.3 NP_766317.1 nucleotide-binding oligomerization domain-containing protein 1
NM_001171007.1 NP_001164478.1 nucleotide-binding oligomerization domain-containing protein 1
NM_001171007.1 NP_001164478.1 nucleotide-binding oligomerization domain-containing protein 1
NM_172729.3 NP_766317.1 nucleotide-binding oligomerization domain-containing protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables pattern recognition receptor activity IDA
IDA: Inferred from direct assay
18261938 MGI
enables peptidoglycan binding IDA
IDA: Inferred from direct assay
16211083 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19898471 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
18261938 MGI
acts upstream of JNK cascade IDA
IDA: Inferred from direct assay
18261938 MGI
acts upstream of or within defense response to Gram-positive bacterium IGI
IGI: Inferred from genetic interaction
18261938 MGI
acts upstream of or within defense response to Gram-positive bacterium IMP
IMP: Inferred from mutant phenotype
18261938 MGI
acts upstream of interleukin-6 production IGI
IGI: Inferred from genetic interaction
18261938 MGI
acts upstream of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
18261938 MGI
acts upstream of macrophage cytokine production IGI
IGI: Inferred from genetic interaction
18261938 MGI
acts upstream of macrophage cytokine production IMP
IMP: Inferred from mutant phenotype
18261938 MGI
involved in nucleotide-binding oligomerization domain containing 1 signaling pathway IDA
IDA: Inferred from direct assay
27007849 MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
18261938 MGI
acts upstream of or within positive regulation of JNK cascade IDA
IDA: Inferred from direct assay
18261938 MGI
involved in positive regulation of autophagy IDA
IDA: Inferred from direct assay
19898471 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
18261938 MGI
involved in positive regulation of dendritic cell antigen processing and presentation IMP
IMP: Inferred from mutant phenotype
20008287 MGI
acts upstream of or within positive regulation of interleukin-6 production IGI
IGI: Inferred from genetic interaction
18261938 MGI
acts upstream of or within positive regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
18261938 MGI
acts upstream of or within positive regulation of macrophage cytokine production IGI
IGI: Inferred from genetic interaction
18261938 MGI
acts upstream of or within positive regulation of macrophage cytokine production IMP
IMP: Inferred from mutant phenotype
18261938 MGI
acts upstream of or within positive regulation of stress-activated MAPK cascade IDA
IDA: Inferred from direct assay
18261938 MGI
acts upstream of or within positive regulation of tumor necrosis factor production IGI
IGI: Inferred from genetic interaction
18261938 MGI
acts upstream of or within positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
18261938 MGI
acts upstream of or within positive regulation of xenophagy IMP
IMP: Inferred from mutant phenotype
22033934 MGI
involved in response to endoplasmic reticulum stress IDA
IDA: Inferred from direct assay
27007849 MGI
acts upstream of stress-activated MAPK cascade IDA
IDA: Inferred from direct assay
18261938 MGI
acts upstream of tumor necrosis factor production IGI
IGI: Inferred from genetic interaction
18261938 MGI
acts upstream of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
18261938 MGI
acts upstream of xenophagy IMP
IMP: Inferred from mutant phenotype
22033934 MGI
Cellular Component GO Annotation Evidence References Source
located in phagocytic vesicle IDA
IDA: Inferred from direct assay
31649195 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nod1 Protein Structure

DD

DD: cl14633 (20 - 103)

NACHT

NACHT: pfam05729 (196 - 366)

NOD2_WH

NOD2_WH: pfam17779 (459 - 514)

NLRC4_HD2

NLRC4_HD2: cl39284 (516 - 664)

PPP1R42

PPP1R42: cl42388 (727 - 940)

LRR_RI

LRR_RI: sd00033 (729 - 756)

LRR_RI

LRR_RI: sd00033 (757 - 784)

LRR_RI

LRR_RI: sd00033 (785 - 812)

LRR_RI

LRR_RI: sd00033 (813 - 840)

LRR_RI

LRR_RI: sd00033 (841 - 868)

LRR_RI

LRR_RI: sd00033 (869 - 896)

LRR_RI

LRR_RI: sd00033 (897 - 924)

LRR_RI

LRR_RI: sd00033 (925 - 945)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 953 a.a.
Protein Preferred Names Protein Names

nucleotide-binding oligomerization domain-containing protein 1

  • caspase recruitment domain 4

  • caspase recruitment domain-containing protein 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (19)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18639 Nodinitib-1 Inhibitor 99.94% Unkown
HY-100691 NOD-IN-1 Inhibitor 99.48% Unkown
HY-P5522A TriDAP dihydrochloride Activator 99.16% Unkown
HY-P5524A C12-iE-DAP hydrochloride Agonist 96.59% Unkown
HY-147506 NOD2 antagonist 1 Antagonist 99.57% Unkown
HY-168023 NOD1-IN-1 Inhibitor / Unkown
HY-184472 NOD1 agonist-1 Agonist / Unkown
HY-178899 C14-Tri-LAN-Gly Agonist / Unkown
HY-184473 NOD1/TLR7 agonist-1 Agonist / Unkown
HY-146034 NOD1/2 antagonist-1 Antagonist / Unkown
HY-123925 CSLP43 Inhibitor / Unkown
HY-170447 NOD1 antagonist-2 Antagonist / Unkown
HY-159965 NOD1-RIPK2-IN-1 Inhibitor / Unkown
HY-168024 NOD1/2-IN-1 Inhibitor / Unkown
HY-101927 NOD1/2 antagonist-2 Antagonist / Unkown
HY-P5524 C12-iE-DAP Agonist / Unkown
HY-P5522 TriDAP Activator / Unkown
HY-163274 NOD1 antagonist-1 Antagonist / Unkown
HY-184814 C14-Ala-D-Glu-(γ-meso)-LAN-Gly(OH) Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nod1 NCBI NCBI:10392