Atic - 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Gene

Also Known as 2610509C24Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 108147

Summary

Enables IMP cyclohydrolase activity and phosphoribosylaminoimidazolecarboxamide formyltransferase activity. Involved in purine ribonucleoside monophosphate biosynthetic process. Acts upstream of or within cellular response to interleukin-7. Located in mitochondrion. Is expressed in several structures, including alimentary system; heart; nervous system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in purine-pyrimidine metabolic disorder. Orthologous to human ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase). [provided by Alliance of Genome Resources, Apr 2022]

Atic Products (1)

mRNA Protein Name
NM_026195.3 NP_080471.2 bifunctional purine biosynthesis protein ATIC

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables IMP cyclohydrolase activity IMP
IMP: Inferred from mutant phenotype
6480832 MGI
enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity IMP
IMP: Inferred from mutant phenotype
26144885 MGI
Biological Process GO Annotation Evidence References Source
involved in 'de novo' AMP biosynthetic process IMP
IMP: Inferred from mutant phenotype
26144885 MGI
involved in 'de novo' IMP biosynthetic process IMP
IMP: Inferred from mutant phenotype
26144885 MGI
involved in 'de novo' XMP biosynthetic process IMP
IMP: Inferred from mutant phenotype
26144885 MGI
involved in GMP biosynthetic process IMP
IMP: Inferred from mutant phenotype
26144885 MGI
acts upstream of or within cellular response to interleukin-7 IDA
IDA: Inferred from direct assay
29581031 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bifunctional purine biosynthesis protein ATIC

  • AICAR transformylase/inosine monophosphate cyclohydrolase

  • bifunctional purine biosynthesis protein PURH

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-N0485 Liensinine Diperchlorate Inhibitor 99.96% Phase 2
HY-135238 (rel)-RSD 921 Agonist / Phase 2
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990067 Evunzekibart Inhibitor 97.02% Phase 1

Pre-clinical Phase

Bioactive Molecules (18)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0499 Cyanidin Chloride Inhibitor 99.43% Unkown
HY-W011927 4,4'-Sulfonyldiphenol 99.81% Unkown
HY-150252A ATIC-IN-1 acetate 99.96% Unkown
HY-133157 FAICAR 85.81% Unkown
HY-N1448 Vincetoxicoside B Inhibitor 99.70% Unkown
HY-29244 ATIC-IN-2 Inhibitor 98.0% Unkown
HY-150252 ATIC-IN-1 99.69% Unkown
HY-N0499A Cyanidin Inhibitor / Unkown
HY-RS01156 ATIC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-141324 Tetraethyl butane-​1,​4-​diylbis(phosphoramid​ate) / Unkown
HY-178468 PARP1-IN-47 Inhibitor / Unkown
HY-182246 MC2050 Inhibitor / Unkown
HY-N17727 Divaricatol / Unkown
HY-N20707 Castalagin / Unkown
HY-RS01126 ATE1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-136263 Biotin-NAD+ Substrate / Unkown
HY-RS17124 Atic Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23569 Atic Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atic NCBI NCBI:471